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Buspirone hydrochloride

Buspirone hydrochloride structure

CAS No:
33386-08-2
Formula:
C21H31N5O2.ClH
Chemical Name:
Buspirone hydrochloride
Synonyms:
8-Azaspiro[4.5]decane-7,9-dione,8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-,hydrochloride (1:1);8-Azaspiro[4.5]decane-7,9-dione,8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-,monohydrochloride;1,1-Cyclopentanediacetimide,N-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-,monohydrochloride;8-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione hydrochloride;MJ 9022-1;Buspirone hydrochloride;Buspirone monohydrochloride;Bespar;Buspar;Axoren;Buspimem;Ansiced;Narol;Censpar;Buspinol;Travin;Buspisal;Ansial;Lucelan;Buspa;Ansiten;Buscalma;Busron
Categories:
Active Pharmaceutical Ingredients > Nervous System Drugs

Description

Buspirone hydrochloride is an anxiolytic psychotropic drug, is used to treat generalized anxiety disorder (GAD).

Buspirone hydrochloride is a hydrochloride salt resulting from the reaction of equimolar amounts of buspirone and hydrogen chloride. It has a role as an anxiolytic drug, an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor, a sedative and a serotonergic agonist. It contains a buspirone(1+).|Buspirone Hydrochloride is the hydrochloride salt of an anxiolytic agent chemically and pharmacologically unrelated to benzodiazepines, barbiturates, or other sedative/hypnotic drugs. Although its exact mechanism of action is unknown, buspirone may exert its anti-anxiety effects via serotonin (5-HT1A) and dopamine receptors (D2) and may indirectly affect other neurotransmitter systems. Unlike typical benzodiazepine anxiolytics, this agent does not exert anticonvulsant or muscle relaxant effects and lacks prominent sedative effects.|An anxiolytic agent and serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the BENZODIAZAPINES, but it has an efficacy comparable to DIAZEPAM.

Buspirone hydrochloride Basic Attributes

Molecular Weight：

421.96

Exact Mass：

421.22400

EC Number：

251-489-4

UNII：

207LT9J9OC

NSC Number：

759571|751138

DSSTox ID：

DTXSID1037193

NCI Thesaurus Code：

C26641

HScode：

2933990090

Characteristics

PSA：

69.6

XLogP3：

2.83100

Appearance：

white solid

Density：

1.24g/cm3

Melting Point：

201.5-202.5 °C

Boiling Point：

613.9ºC at 760mmHg

Flash Point：

9℃

Water Solubility：

Soluble in methanol (50 mg/ml), water (partly), DMSO (100 mM).

Storage Conditions：

2-8°C

Toxicity：

LD50 i.p. in rats: 136 mg/kg (Allen)

Collision Cross Section：

197.7 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Hazard category：

6.1

Transport codes：

UN 2811 6.1/PG 3

wgk germany：

hazard class code：

25-36/37/38-20/21/22-39/23/24/25-23/24/25-11

safety instructions：

45-36-26-36/37-16

RTECS Number：

CL9915000

Marks：

T,Xn,F

Precautionary statement(s)：

P210-P260-P280-P301 + P310-P311

Hazard Statements：

H225-H301 + H311 + H331-H370

GHS Classification：

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P301+P310, P321, P330, P405, and P501|Aggregated GHS information provided by 46 companies from 3 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here. (See all compounds classified as Anti-Anxiety Agents.)|Endogenous compounds and drugs that bind to and activate SEROTONIN RECEPTORS. Many serotonin receptor agonists are used as ANTIDEPRESSANTS; ANXIOLYTICS; and in the treatment of MIGRAINE DISORDERS. (See all compounds classified as Serotonin Receptor Agonists.)

MeSH Entry Terms：

Anxut

Buspirone hydrochloride Use and Manufacturing

Uses

anxiolitic;serotonin receptor agonist

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:422.0
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:421.2244530
Monoisotopic Mass:421.2244530
Topological Polar Surface Area:69.6
Heavy Atom Count:29
Complexity:529
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Material

Sodium hydroxide

Sodium carbonate

Isopropanol

Dimethylformamide

Hydrochloric acid

Drug Function and Efficacy

The specific pharmacological effects are not clearly described from the above information

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Buspirone Hydrochloride

Buspirone Hydrochloride Tablets
Ingredients	Buspirone Hydrochloride
Indication	The combined use of this product with monoamine oxidase inhibitors may increase blood pressure.
Specifications	5 mg
Manufacturer	PKU HealthCare Corp., Ltd.

Buspirone Hydrochloride Tablets
Ingredients	Buspirone Hydrochloride
Indication	The combined use of this product with monoamine oxidase inhibitors may increase blood pressure.
Specifications	5 mg
Manufacturer	Jiangsu Nhwa Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

R L Fine Chem Pvt Ltd

United States
Active
MAITHRI LABORATORIES PRIVATE LTD

United States
Active
EMCURE PHARMACEUTICALS LTD

United States
Active

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