Idebenone
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Idebenone
structure -
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CAS No:
58186-27-9
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Formula:
C19H30O5
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Chemical Name:
Idebenone
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Synonyms:
2,5-Cyclohexadiene-1,4-dione,2-(10-hydroxydecyl)-5,6-dimethoxy-3-methyl-;2-(10-Hydroxydecyl)-5,6-dimethoxy-3-methyl-2,5-cyclohexadiene-1,4-dione;2,3-Dimethoxy-5-methyl-6-(10-hydroxydecyl)-1,4-benzoquinone;CV 2619;Idebenone;2,3-Dimethoxy-6-(10-hydroxydecyl)-5-methyl-1,4-benzoquinone;Avan;Daruma;Mnesis;2-(10-Hydroxydecyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione;Raxone;2-(10-Hydroxy-decyl)-5,6-dimethoxy-3-methyl-[1,4]benzoquinone;Sovrima
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CAS No:
Description
Idebenone is a synthetic variant of coenzyme Q10 (CoQ10), which initially developed for the treatment of Alzheimer's disease and other cognitive defects.Target: OthersIdebenone is a synthetic variant of coenzyme Q10 (CoQ10), which initially developed for the treatment of Alzheimer's disease and other cognitive defects. Idebenone was generally well tolerated with similar numbers of adverse events in each group. One child receiving high-dose idebenone developed neutropenia after 6 months,
Idebenone is a member of the class of 1,4-benzoquinones which is substituted by methoxy groups at positions 2 and 3, by a methyl group at positions 5, and by a 10-hydroxydecyl group at positions 6. Initially developed for the treatment of Alzheimer's disease, benefits were modest; it was subsequently found to be of benefit for the symptomatic treatment of Friedreich's ataxia. It has a role as an antioxidant and a ferroptosis inhibitor. It is a primary alcohol and a member of 1,4-benzoquinones.
Idebenone Basic Attributes
338.44
338.44
1308068-626-2
HB6PN45W4J
759228
DTXSID0040678
N06BX13|N - Nervous system
Characteristics
72.8
4.3
Yellow-orange crystalline powder
1.1±0.1 g/cm3
46-50 °C
497.3ºC at 760 mmHg
170.1±22.2 °C
1.502
room temp
178.6 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Safety Information
NONH for all modes of transport
3
GU5290000
Xi
Stable at normal temperatures and pressures.
|Warning|H228 (50%): Flammable solid [Danger Flammable solids]|P210, P240, P241, P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P370+P378, P403+P233, P405, and P501|Aggregated GHS information provided by 3 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Raxone is indicated for the treatment of visual impairment in adolescent and adult patients with Leber's Hereditary Optic Neuropathy (LHON).|Treatment of Friedreich�s Ataxia
Naturally occurring or synthetic substances that inhibit or retard oxidation reactions. They counteract the damaging effects of oxidation in animal tissues. (See all compounds classified as Antioxidants.)
CV 2619
Idebenone Use and Manufacturing
Ubiquinone derivative with protective effects against cerebral ischemia. Nootropic The brain function improving agent can improve brain energy metabolism, improve brain function, and have a mild hypotensive effect. It is clinically used for patients with cerebral infarction, cerebral hemorrhage and sequelae of arteriosclerosis caused by brain dysfunction, low consciousness, mood disorders, language disorders, dementia, etc. Central nervous system stimulant. Used as a medicine for improving cerebral circulation, a medicine for promoting intelligence
Human drugs -> Orphan -> Raxone -> EMA Drug Category|Psychoanaleptics, Other psychostimulants and nootropics -> Human pharmacotherapeutic group|Human drugs -> Orphan -> Sovrima -> EMA Drug Category|Psychoanaleptics -> Human pharmacotherapeutic group|Human drugs -> Rare disease (orphan)
Computed Properties
Molecular Weight:338.4
XLogP3:4.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:12
Exact Mass:338.20932405
Monoisotopic Mass:338.20932405
Topological Polar Surface Area:72.8
Heavy Atom Count:24
Complexity:502
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Drug Function and Efficacy
This product is a drug for improving brain metabolism and mental symptoms. It can activate the respiratory activity of brain mitochondria, improve brain energy metabolism in cerebral ischemia, improve the utilization of glucose in the brain, increase the production of ATP in the brain, inhibit the production of lipid peroxides in brain mitochondria, and inhibit membrane disorders caused by lipid peroxidation of brain mitochondrial membranes.
Registered Holders
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INDUSTRIALE CHIMICA S.R.L.
Active
Italy
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Shandong Lixin Pharmaceutical Co., Ltd.
Active
China
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Qilu Pharmaceutical Co., Ltd.
Active
China
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