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Malotilate

Malotilate structure

CAS No:
59937-28-9
Formula:
C12H16O4S2
Chemical Name:
Malotilate
Synonyms:
Propanedioic acid,2-(1,3-dithiol-2-ylidene)-,1,3-bis(1-methylethyl) ester;Propanedioic acid,1,3-dithiol-2-ylidene-,bis(1-methylethyl) ester;1,3-Dithiole,propanedioic acid deriv.;Diisopropyl 1,3-dithiol-2-ylidenemalonate;NKK 105;Malotilate;Hepation;Kantec
Categories:
Active Pharmaceutical Ingredients > Digestive System Drugs

Description

Malotilate is a liver protein metabolism improved compound, which selectively inhibit the 5-lipoxygenase. IC50 Value:Target: 5-lipoxygenasein vitro: In an in vitro invasion assay using rat lung endothelial (RLE) cells, invasion of tumor cells which had been treated with MT (10 ng/ml, 24 h) was not affected; however, when RLE cells had been treated with MT, invasion was significantly inhibited in three cell lines (SAS, Ca9-22 and HSC-4) and a tendency to inhibition was also observed in ot

Malotilate is an isopropyl ester.

Malotilate Basic Attributes

Molecular Weight：

288.38

Exact Mass：

288.38

EC Number：

261-987-3

UNII：

RV59PND975

DSSTox ID：

DTXSID7046463

Characteristics

PSA：

103

XLogP3：

3.8

Density：

1.320 g/cm³

Melting Point：

60.5 °C

Boiling Point：

321.5°C at 760 mmHg

Flash Point：

138.7±15.9 °C

Refractive Index：

1.562

Safety Information

hazard class code：

R36/37/38:Irritating to eyes, respiratory system and skin .

safety instructions：

S26-S36/37/39

RTECS Number：

OO0970000

Marks：

Drug Information

MeSH Entry Terms：

diisopropyl 1,3-dithiol-2-ylidenemalonate

Malotilate Use and Manufacturing

Hepatitis adjuvant medication is used to improve liver function in compensatory cirrhosis.

Computed Properties

Molecular Weight:288.4
XLogP3:3.8
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:288.04900133
Monoisotopic Mass:288.04900133
Topological Polar Surface Area:103
Heavy Atom Count:18
Complexity:363
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Unspecified

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Malotiate

Malotiate Tablets
Ingredients	The main ingredient of this product is: malotiate. Its chemical name is: 1,3-dithioxo-2-ylidene-malonic acid diisopropyl ester.
Specifications	0.1g
Manufacturer	Henan Life Pharmaceutical Co., Ltd.

Malotiate Tablets
Ingredients	The main ingredient of this product is: malotiate. Its chemical name is: 1,3-dithioxo-2-ylidene-malonic acid diisopropyl ester.
Indication	Not yet clear.
Specifications	0.1g
Manufacturer	Jinzhou Jiutai Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

Yabao PHARMA Sichuan Pharmaceutical Co., Ltd.

China
Active
Changzhou Yabang Pharmaceutical Co., Ltd.

China
Active
Jinzhou Jiutai Pharmaceutical Co., Ltd.

China
Active

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HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

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CAS No.: 59937-28-9

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Hangzhou KieRay Chem Co.,LTD Contact Supplier

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Malotilate

CAS No.: 59937-28-9

Grade: industrial Grade

Content: 98%

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