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Nefiracetam

Nefiracetam structure

CAS No:
77191-36-7
Formula:
C14H18N2O2
Chemical Name:
Nefiracetam
Synonyms:
1-Pyrrolidineacetamide,N-(2,6-dimethylphenyl)-2-oxo-;N-(2,6-Dimethylphenyl)-2-oxo-1-pyrrolidineacetamide;DM 9384;DMPPA;Nefiracetam;2-(2-Oxo-1-pyrrolidinyl)-N-(2,6-dimethylphenyl)acetamide;N-(2,6-Dimethylphenyl)-2-(2-oxo-1-pyrrolidinyl)acetamide;Translon;DZL 221;DMMPA
Categories:
Active Pharmaceutical Ingredients > Nervous System Drugs

Description

Nefiracetam is a GABAergic, cholinergic, and monoaminergic neuronal systems enhancer for Ro 5-4864-induced convulsions.Target: GABA ReceptorNefiracetam induces a short-term depression of ACh-evoked currents at submicromolar concentrations (0.01-0.1 μM) and a long-term enhancement of the currents at micromolar concentrations (1-10 μM). Nefiracetam interacts with PKA and PKC pathways, which may explain a cellular mechanism for the action of cognition-enhancing agents. Lower (submicromolar)

Nefiracetam is an organooxygen compound and an organonitrogen compound. It derives from an alpha-amino acid.|Nefiracetam has been used in trials studying the treatment of Alzheimer's Disease.

Nefiracetam Basic Attributes

Molecular Weight：

246.3

Exact Mass：

246.30

EC Number：

1308068-626-2

UNII：

1JK12GX30N

NSC Number：

759830

DSSTox ID：

DTXSID2020923

HScode：

2933790090

Characteristics

PSA：

49.4

XLogP3：

1.4

Appearance：

white to off-white

Density：

1.2±0.1 g/cm3

Melting Point：

153 °C

Boiling Point：

458.5°C at 760 mmHg

Flash Point：

231.1±25.4 °C

Refractive Index：

1.594

Water Solubility：

DMSO: >5mg/mL

Storage Conditions：

Store at RT

Toxicity：

LD50 in mice (mg/kg): 421 i.v.; 1766 orally (Betzing, 1982)

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

RTECS Number：

UX9655650

Marks：

Precautionary statement(s)：

P305 + P351 + P338

Hazard Statements：

H302-H319

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P280, P301+P312, P305+P351+P338, P330, P337+P313, and P501|Aggregated GHS information provided by 40 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

A class of drugs producing both physiological and psychological effects through a variety of mechanisms. They can be divided into "specific" agents, e.g., affecting an identifiable molecular mechanism unique to target cells bearing receptors for that agent, and "nonspecific" agents, those producing effects on different target cells and acting by diverse molecular mechanisms. Those with nonspecific mechanisms are generally further classed according to whether they produce behavioral depression or stimulation. Those with specific mechanisms are classed by locus of action or specific therapeutic use. (From Gilman AG, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p252) (See all compounds classified as Central Nervous System Agents.)|Drugs used to specifically facilitate learning or memory, particularly to prevent the cognitive deficits associated with dementias. These drugs act by a variety of mechanisms. (See all compounds classified as Nootropic Agents.)|Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids. (See all compounds classified as Neuroprotective Agents.)|A loosely defined grouping of drugs that have effects on psychological function. Here the psychotropic agents include the antidepressive agents, hallucinogens, and tranquilizing agents (including the antipsychotics and anti-anxiety agents). (See all compounds classified as Psychotropic Drugs.)

MeSH Entry Terms：

DM 9384

Nefiracetam Use and Manufacturing

analgesic, antiinflammatory

Computed Properties

Molecular Weight:246.30
XLogP3:1.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:246.136827821
Monoisotopic Mass:246.136827821
Topological Polar Surface Area:49.4
Heavy Atom Count:18
Complexity:320
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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