Manidipine dihydrochloride
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Manidipine dihydrochloride
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CAS No:
89226-75-5
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Formula:
C35H38N4O6.2ClH
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Chemical Name:
Manidipine dihydrochloride
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Synonyms:
3,5-Pyridinedicarboxylic acid,1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-,3-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl] 5-methyl ester,hydrochloride (1:2);3,5-Pyridinedicarboxylic acid,1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-,2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester,dihydrochloride;CV 4093;Franidipine hydrochloride;(±)-Manidipine dihydrochloride;Calslot;Manidipine dihydrochloride;126229-12-7
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Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs
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CAS No:
Description
Manidipine 2Hcl (CV-4093) is a dihydropyridine compound and a calcium channel blocker for Ca2+ current with IC50 of 2.6 nM. IC50 value: 2.6 nMTarget: calcium channelManidipine is described to block T-type Ca2+ channels specifically and is also described to have a high selectivity for the vasculature, presenting negligible cardiodepression as compared to other Ca2+ channel antagonists. Manidipine is also described to not significantly affect norepinephrine levels, suggesting a lack of sym
Manidipine dihydrochloride is a diarylmethane.
Characteristics
117
6.48280
157-163°; mp 174-180°; mp 167-170°
722ºC at 760 mmHg
Soluble in DMSO. Slightly soluble in water and ethanol /n
LD50 in male, female mice, male, female rats (mg/kg): 387, 340, 222, 199 s.c.; 62.2, 68.0, 66.5, 48.8 i.p.; 190, 171, 247, 156 orally (Chiba)
Safety Information
6.1
UN 2811 6.1/PG III
US7975300
P201, P202, P260, P261, P264, P270, P271, P280, P281, P301+P310, P302+P352, P304+P340, P308+P313, P311, P312, P314, P321, P322, P330, P361, P363, P403+P233, P405, P501
H301+H311+H331
|Danger|H301+H311+H331 (20%): Toxic if swallowed, in contact with skin or if inhaled [Danger Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]|P201, P202, P260, P261, P264, P270, P271, P280, P281, P301+P310, P302+P352, P304+P340, P308+P313, P311, P312, P314, P321, P322, P330, P361, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 6 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)|A class of drugs that act by selective inhibition of calcium influx through cellular membranes. (See all compounds classified as Calcium Channel Blockers.)
(+)-manidipine
Manidipine dihydrochloride Use and Manufacturing
The manidipine alkali 2.25 kg added to the dichloromethane 6.75 L, methanol 4.5 L after dissolving cooling to 0 - 10 °C, drops of concentrated hydrochloric acid 1.07 L, after adding, thermal insulation stirring reaction 1 h, then adding methyl tert-butyl ether 13.5 L, then stirring 1 h, a large number of solid precipitation, filtering, washing the cake with a small amount of methyl tert-butyl ether, dichloromethane is used for the filter cake 22 L reflux beating 1 h, cooling to room temperature, filtering. A small amount of methyl tert-butyl ether cake washing, 40 - 50 °C blast drying, to obtain 2.05 kg yellow solid. The yield is 81.8percent, purity 99.8869percent.
Manidipine Dihydrochloride is a metabolite of Manidipine (M16400), a dihydropyridine calcium channel blocker that exhibits antihypertensive properties.
Computed Properties
Molecular Weight:683.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:11
Exact Mass:682.2324904
Monoisotopic Mass:682.2324904
Topological Polar Surface Area:117
Heavy Atom Count:47
Complexity:1090
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes
Registered Holders
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JEIL PHARMACEUTICAL CO.,LTD.
Active
South Korea
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Haisco Pharmaceutical(Meishan) Co., Ltd.
Active
China
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Xuchang HENGSHENG Pharmaceutical Co., Ltd.
Active
China
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