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8-Bromoquinoline

8-Bromoquinoline structure

CAS No:
16567-18-3
Formula:
C9H6BrN
Chemical Name:
8-Bromoquinoline
Synonyms:
Quinoline,8-bromo-;8-Bromoquinoline
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

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Description

white to light yellow crystal powder

8-Bromoquinoline Basic Attributes

Molecular Weight：

208.05

Exact Mass：

208.05

DSSTox ID：

DTXSID10168009

HScode：

29334900

Characteristics

PSA：

12.9

XLogP3：

2.5

Appearance：

Clear yellow to yellow-brown Liquid After Melting

Density：

1.594 g/mL at 25 °C(lit.)

Melting Point：

80 °C @ Solvent: Diethyl ether

Boiling Point：

302 °C

Flash Point：

>230 °F

Refractive Index：

n20/D 1.672(lit.)

Storage Conditions：

Refrigerator (+4°C)

Vapor Pressure：

0.002mmHg at 25°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38

safety instructions：

26-36-37/39

Marks：

Hazard note：

Irritant

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H315-H319-H335

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 46 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

8-Bromoquinoline Use and Manufacturing

Methods of Manufacturing

General procedure: A 1N HCl solution (82.5 mL) was added to the aniline (~1 mmol) in a round bottom flask. To this was added acrolein diethyl acetal (2.5 mmol). The resulting solution was refluxed at 111 °C for 24 hours. After cooling to room temperature, the solution was neutralized (pH 7−8) by addition of solid Na2CO3. The product was then extracted into dichloromethane (3 x 100 mL), and the combined organic layers were dried over Na2SO4 and evaporated under reduced pressure. The crude residue was then purified by column chromatography (elution mixture of hexane with ethyl acetate or 15percent ethyl acetate/cyclohexane with methanol) to give the desired quinoline product.

Uses

Pharmaceutical and pesticide intermediates

Computed Properties

Molecular Weight:208.05
XLogP3:2.5
Hydrogen Bond Acceptor Count:1
Exact Mass:206.96836
Monoisotopic Mass:206.96836
Topological Polar Surface Area:12.9
Heavy Atom Count:11
Complexity:138
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Glycerol

Sulfuric acid

Recommended Suppliers of 8-Bromoquinoline

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

8-Bromoquinoline

CAS No.: 16567-18-3

Content: 99.00%

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NANTONG REFORM PETRO-CHEMICAL CO.,LTD Contact Supplier

CN
4 YRS

Business licensed Certified factory

Manufactory Supplier of Flavors & Fragrances,Catalyst & Auxiliary,Intermediates,Dyes & Pigments,Inorganic Chemistry,petro chemicals,Surfactant,Food Additives,Water Treatment Chemicals

8-Bromoquinoline

CAS No.: 16567-18-3

Grade: Industrial Grade

Content: 98%

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