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5-BROMO-2-CHLORO-3-METHOXYPYRIDINE

5-BROMO-2-CHLORO-3-METHOXYPYRIDINE structure

CAS No:
286947-03-3
Formula:
C6H5BrClNO
Chemical Name:
5-BROMO-2-CHLORO-3-METHOXYPYRIDINE
Synonyms:
5-bromo-2-chloro-3-methoxypyridine;5-Bromo-2-chloro-3-methoxy-pyridine;Pyridine, 5-bromo-2-chloro-3-methoxy-;MFCD08234976;KSC496C6L;SCHEMBL608749;CTK3J6165;DTXSID10587791;2-Chloro-3-methoxy-5-bromopyridine;ANW-53971
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

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5-BROMO-2-CHLORO-3-METHOXYPYRIDINE Basic Attributes

Molecular Weight：

222.47

Exact Mass：

220.924301

DSSTox ID：

DTXSID10587791

HScode：

2933399090

Characteristics

PSA：

22.1

XLogP3：

2.5

Density：

1.6±0.1 g/cm3

Melting Point：

68-72°C

Boiling Point：

245.617ºC at 760 mmHg

Flash Point：

102.3±25.9 °C

Refractive Index：

1.560

Vapor Pressure：

0.045mmHg at 25°C

Safety Information

Packing level：

Ⅲ

Hazard category：

IRRITANT

Transport codes：

2811

wgk germany：

hazard class code：

22-41-25

safety instructions：

26-39-45

Marks：

Xn,T

Precautionary statement(s)：

P280-P301 + P310-P305 + P351 + P338

Hazard Statements：

H301-H318

GHS Classification：

|Danger|H301 (97.5%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P280, P301+P310, P305+P351+P338, P310, P321, P330, P405, and P501|Aggregated GHS information provided by 40 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

5-BROMO-2-CHLORO-3-METHOXYPYRIDINE Use and Manufacturing

Step 3: Example 51A The product from Example 40B (1.2 g, 5.8 mmol) in diethyl ether (5 mL) was added to a suspension of NaH (181 mg, 7.5 mmol) in dry DMF (30 mL) and diethyl ether (6 mL). After stirring at ambient temperature for 30 minutes, the mixture was treated with a solution of iodomethane (1.06 g, 7.5 mmol) in diethyl ether (3 mL) and stirring was continued for an additional 30 minutes. The reaction mixture was quenched with water (20 mL), extracted with diethyl ether (100 mL), dried (MgSO4), and concentrated under reduced pressure. The residue was purified on SiO2 (ethyl acetate/hexane, 1/4) to provide the title compound (0.32 g, 25percent) as a colorless oil. MS (DCI/NH3) m/z 222/224/226 (M+H)+.A suspension of NaH (0.181 g, 7.5 mmol) in dry DMF (30 mL) and diethyl ether (6 mL) was treated with the product from Example 23B (1.2 g, 5.8 mmol) in diethyl ether (5 mL). After stirring at ambient temperature for 30 minutes, the mixture was treated with a solution of iodomethane (1.06 g, 7.5 mmol) in diethyl ether (3 mL). After stirring for 30 minutes, the mixture was quenched with water (20 mL), extracted with diethyl ether (100 mL), dried (MgSO4) and concentrated under reduced pressure. The crude was purified on SiO2 (ethyl acetate:hexane, 1:4) to provide the title compound as a colorless oil (0.32 g, 25percentprovide). MS(DCI/NH3) m/z 222/224/226 (M+H)+.Phosphoryl chloride (POClb. Preparation of Compound Phosphoryl chloride (POClTo a mixture of 3-bromo-5-methoxypyridine 1-oxide (2 g 9.80 mmol) in DCM (40 mL) was added POCl

Computed Properties

Molecular Weight:222.47
XLogP3:2.5
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:220.92430
Monoisotopic Mass:220.92430
Topological Polar Surface Area:22.1
Heavy Atom Count:10
Complexity:114
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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5-Bromo-2-chloro-3-methoxypyridine

CAS No.: 286947-03-3

Content: 99.00%

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Shaanxi Kaierkai Pharmaceutical Technolo Contact Supplier

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Trader Supplier of 1,9-DIAMINONONANE,3-BUTYLPYRIDINE,1,3,5-Tris(trifluoromethyl)benzene,3-N-PROPYLPHENOL,Meclofenamic acid,4-Pentyloxyphenol,GERANIC ACID,gidazepam,2-(4-ethylbenzoyl)benzoic acid,METHYL 3-OXOTETRADECANOATE,1,5-DIMETHYL-2-PYRROLIDINONE,Tetradecanoic acid,3-[(1-oxotetradecyl)oxy]-,(R)-,1-OCTANESULFONYL CHLORIDE,3-Hydroxy Myristic Acid Methyl Ester

5-BROMO-2-CHLORO-3-METHOXYPYRIDINE KEK

CAS No.: 286947-03-3

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Guide of 5-BROMO-2-CHLORO-3-METHOXYPYRIDINE

Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
Latest News
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5-BROMO-2-CHLORO-3-METHOXYPYRIDINE

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