2,4-Dichloro-6-methyl-5-pyrimidinecarboxylic acid methyl ester
-
2,4-Dichloro-6-methyl-5-pyrimidinecarboxylic acid methyl ester
structure -
-
CAS No:
36745-93-4
-
Formula:
C7H6Cl2N2O2
-
Chemical Name:
2,4-Dichloro-6-methyl-5-pyrimidinecarboxylic acid methyl ester
-
Synonyms:
(S)-methyl 2-(morpholin-3-yl)acetate HCL;methyl 2,4-dichloro-6-methylpyrimidine-5-carboxylatemethyl 2,4-dichloro-6-methylpyrimidine-5-carboxylate;2,4-Dichloro-6-methyl-5-pyrimidinecarboxylic acid methyl ester;Methyl 2,4-dichloro-6-methylpyrimidine-5-carboxylate;(3-BROMOPHENYL)(3-PYRIDINYL)METHANONE
- Categories:
-
CAS No:
2,4-Dichloro-6-methyl-5-pyrimidinecarboxylic acid methyl ester Basic Attributes
221.04074
219.980637
DTXSID50727038
2933599090
2,4-Dichloro-6-methyl-5-pyrimidinecarboxylic acid methyl ester Use and Manufacturing
Preparation 1Methyl 2, 4-dichloro-6-methylpyrimidine-5-carboxylate To a suspension of methyl 6-methyl-2, 4-dioxo-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylate (1 g, 5.43 mmol) in POClSynthesis of compound 1.5. A solution of 1.4 (12.1 g, 0.06576 mol, 1.00 equiv) in phosphorusoxychloride (120ml) was heated at 110 °C for 2 hrs. After completion, reaction mixture was concentrated under reduced pressure and residue was quenched in ice. The crude product was extracted twice with ethyl acetate. The organic layers were dried over sodium sulfate and concentrated under reduced pressure to afford crude material which was purified by flash column chromatography This resulted in pure compound 1.5 (10.2g, 70.20percent>). MS (ES): m/z 222.8 [M+H]c) 4-Methyl-2, 6-dioxo-3H-pyrimidine-5-carboxylic acid methyl ester (0.64 g, 3.48 mmol) is dissolved in phosphoryl chloride (6.5 ml) and to it is added tributylamine (1.75 ml). The resulting mixture is heated at 95 °C for 3 h. Excess phosphoryl chloride is distilled of and ice-water is added to the reaction mixture and extracted with EtOAc (3 x 30 ml). The combined organic layers are washed with water (30 ml), brine (30ml), evaporated to dryness to get the crude product, which is purified by column chromatography (silica gel, 5percent /hexane) affording 2, 4-dichloro-6-methyl-pyrimidine-5-carboxylic acid methyl ester (0.45 g, 2.04 mmol, 59percent).
Computed Properties
Molecular Weight:221.04
XLogP3:2.4
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:219.9806328
Monoisotopic Mass:219.9806328
Topological Polar Surface Area:52.1
Heavy Atom Count:13
Complexity:203
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of 2,4-Dichloro-6-methyl-5-pyrimidinecarboxylic acid methyl ester
-
![China]()
CN
5 YRS
Business licensedTrader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food AdditivesInquiryCAS No.: 36745-93-4Content: 99.00% -
![China]()
CN
2 YRS
Business licensed Certified factoryManufactory Supplier of 4-(Pentafluorothio)aniline,Pentafluoro,Pentafluorothio,Pentafluorosulfur,[4-(bromomethyl)phenyl]-pentafluoro-lambda6-sulfane,[4-(pentafluoro-sulfanyl)phenyl]acetic acidInquiryCAS No.: 36745-93-4Grade: Industrial GradeContent: 95%
Learn More Other Chemicals
-
Cyclopentanecarboxylic acid, 2-(hydroxyimino)-, methyl ester (9CI)
170016-09-8
-
3-CYCLOPROPYL-2-METHYL-3-OXO-PROPIONIC ACID ETHYL ESTER
21741-37-7
-
CYCLOPENTYL-CARBAMIC ACID PHENYL ESTER
58713-31-8
-
Cysteine, 2-methyl-, methyl ester (9CI) Formula
778548-47-3
-
D-Glucuronal 3,4-Diacetate Methyl Ester Formula
34296-99-6
-
2'-Deoxy-N-trimethylsilyl-3'-O-trimethylsilylcytidine 5'-phosphoric acid bis(trimethylsilyl) ester Formula
32645-72-0
-
4,6-Dichloro-1H-indole-2,3-dicarboxylic acid diethyl ester Structure
146012-24-0
-
2-[(2,6-Dichlorophenyl)sulfonyl]acetic acid ethyl ester Structure
1154228-17-7
-
What is Dibenzoic acid 2-ethylhexamethylene ester
25724-54-3
-
What is 1,4-DIBENZYL-7-PHENYL-6-THIOXO-1,4,7-TRIAZA-SPIRO[4.4]NON-8-ENE-9-CARBOXYLIC ACID ETHYL ESTER
885722-38-3
2,4-Dichloro-6-methyl-5-pyrimidinecarboxylic acid methyl ester
SDSRequest for Quotation