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5-Fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[(5-methyl-1H-pyrazol-3-yl)amino]-3-pyridinecarbonitrile

5-Fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[(5-methyl-1H-pyrazol-3-yl)amino]-3-pyridinecarbonitrile structure

CAS No:
905586-69-8
Formula:
C18H16F2N6
Chemical Name:
5-Fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[(5-methyl-1H-pyrazol-3-yl)amino]-3-pyridinecarbonitrile
Synonyms:
5-Fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[(5-methyl-1H-pyrazol-3-yl)amino]-3-pyridinecarbonitrile;AZ 960;(S)-5-fluoro-2-(1-(4-fluorophenyl)ethylaMino)-6-(5-Methyl-1H-pyrazol-3-ylaMino)nicotinonitrile;5-Fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[(5-methyl-1H-pyrazol-3-yl)amino]-3-pyridinecarbonitrile AZ 960;(S)-5-Fluoro-2-((1-(4-fluorophenyl)ethyl)amino)-6-((5-methyl-1H-pyrazol-3-yl)amino)nicotinonit
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

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Description

AZ960 is a potent and specific inhibitor of the JAK2 kinase with a Ki of 0.45 nM.

5-Fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[(5-methyl-1H-pyrazol-3-yl)amino]-3-pyridinecarbonitrile Basic Attributes

Molecular Weight：

354.36

Exact Mass：

354.140442

UNII：

M63IS9PTJF

DSSTox ID：

DTXSID60238201

Characteristics

PSA：

89.4

XLogP3：

4.4

Density：

1.4±0.1 g/cm3

Flash Point：

265.4±30.1 °C

Refractive Index：

1.628

Drug Information

MeSH Entry Terms：

5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile

Computed Properties

Molecular Weight:354.4
XLogP3:4.4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:5
Exact Mass:354.14045086
Monoisotopic Mass:354.14045086
Topological Polar Surface Area:89.4
Heavy Atom Count:26
Complexity:503
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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AZ 960

CAS No.: 905586-69-8

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Guide of 5-Fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[(5-methyl-1H-pyrazol-3-yl)amino]-3-pyridinecarbonitrile

Description
Basic Attributes
Characteristics
Drug Information
Computed Properties
Recommended Suppliers
Latest News
Learn More Other Chemicals

5-Fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[(5-methyl-1H-pyrazol-3-yl)amino]-3-pyridinecarbonitrile

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