4-IODO-2-METHOXYPYRIDINE

(c) 59.4 g (253 mmol) of the crude product of 2-fluoro-4-iodopyridine obtained in step (b) was added to 500 mL of methanol, and 21.5 g (398 mmol) of sodium methoxide was added, followed by refluxing by heating for 3 hours. 300 mL of water was added to terminate the reaction, and methanol was distilled off under reduced pressure. Extraction with ethyl ether was carried out, then, the organic layer was dried over sodium sulfate and subjected to filtration, and the solvent was distilled off under reduced pressure to obtain 56.7 g (crude yield 91percent) of a crude product of 4-iodo-2-methoxypyridine.1H-NMR(CDCl3, 400 MHz) : δ (ppm) = 3.86(s, 3H), 7.12-7.16(m, 2H), 7.79(d, 1H, J = 5.6 Hz)(c); 500 ml of methanol was added to 59.4 g (253 mmol) of crude 2-fluoro-4-iodopyridine obtained in Step (b) so that it was dissolved in methanol, and 21.5 g (398 mmol) of sodium methoxide was added, followed by reflux with heating for 3 hours. 300 ml of water was added to terminate the reaction, and methanol was distilled off under reduced pressure. After extraction with ethyl ether, the organic layer was dried over sodium sulfate and subjected to filtration, and the solvent was distilled off under reduced pressure to obtain 56.7 g (crude yield: 91percent) of crude 4-iodo-2-methoxypyridine.

Molecular Weight:235.02
XLogP3:1.8
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:234.94941
Monoisotopic Mass:234.94941
Topological Polar Surface Area:22.1
Heavy Atom Count:9
Complexity:89.1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes