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Milrinone lactate

Milrinone lactate structure

CAS No:
100286-97-3
Formula:
C12H9N3O.xC3H6O3
Chemical Name:
Milrinone lactate
Synonyms:
Propanoic acid,2-hydroxy-,compd. with 1,6-dihydro-2-methyl-6-oxo[3,4′-bipyridine]-5-carbonitrile (1:?);Propanoic acid,2-hydroxy-,compd. with 1,6-dihydro-2-methyl-6-oxo[3,4′-bipyridine]-5-carbonitrile;[3,4′-Bipyridine]-5-carbonitrile,1,6-dihydro-2-methyl-6-oxo-,2-hydroxypropanoate;Milrinone lactate;Primacor;Primacor (pharmaceutical)
Categories:
Organic Chemistry > Amides

Description

Milrinone Lactate is a bipyridine agent with positive inotropic and vasodilator properties. Milrinone lactate selectively inhibits fraction III cyclic adenosine monophosphate (cAMP) phosphodiesterase isozymes in the heart and vascular muscles, thereby increasing cAMP and, consequently, an increase in cAMP-dependent intracellular ionized calcium and myocardium contractile force, and vasodilation in arteriolar and venous vascular smooth muscle. This agent improves hemodynamics in patients with ventricular dysfunction by increasing the stroke volume index and left ventricular contractility and by producing pulmonary vasodilation. (NCI04)|A positive inotropic cardiotonic agent with vasodilator properties. It inhibits cAMP phosphodiesterase type 3 activity in myocardium and vascular smooth muscle. Milrinone is a derivative of amrinone and has 20-30 times the inotropic potency of amrinone.

Milrinone lactate Basic Attributes

Molecular Weight：

301.302

Exact Mass：

301.106262

NCI Thesaurus Code：

C29263

Characteristics

PSA：

123

XLogP3：

1.06878

Appearance：

White or whitish crystalline powder

Boiling Point：

448.7ºC at 760 mmHg

Flash Point：

225.2ºC

Vapor Pressure：

3.04E-08mmHg at 25°C

Drug Information

MeSH：

Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE). (See all compounds classified as Cardiotonic Agents.)|Compounds that specifically inhibit PHOSPHODIESTERASE 3. (See all compounds classified as Phosphodiesterase 3 Inhibitors.)|Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system. (See all compounds classified as Platelet Aggregation Inhibitors.)|Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)

MeSH Entry Terms：

Corotrop

Milrinone lactate Use and Manufacturing

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:301.30
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:301.10625597
Monoisotopic Mass:301.10625597
Topological Polar Surface Area:123
Heavy Atom Count:22
Complexity:478
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Pharmacological action not specifically described

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Milrinone Lactate and Glucose Injection
Specifications	100ml: Milrinone 20mg and anhydrous glucose 4.94g

Milrinone Lactate Injection
Specifications	10ml:10mg

Milrinone Lactate Injection
Specifications	10ml:10mg

See More Related Drugs

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Milrinone lactate

CAS No.: 100286-97-3

Content: 99.00%

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