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Lanoconazole

Lanoconazole structure

CAS No:
101530-10-3
Formula:
C14H10ClN3S2
Chemical Name:
Lanoconazole
Synonyms:
1H-Imidazole-1-acetonitrile,α-[4-(2-chlorophenyl)-1,3-dithiolan-2-ylidene]-,(αE)-;1H-Imidazole-1-acetonitrile,α-[4-(2-chlorophenyl)-1,3-dithiolan-2-ylidene]-,(E)-(±)-;(αE)-α-[4-(2-Chlorophenyl)-1,3-dithiolan-2-ylidene]-1H-imidazole-1-acetonitrile;Latoconazole;Lanoconazole;NND 318;TJN 318;1H-Imidazole-1-acetonitrile,α-[4-(2-chlorophenyl)-1,3-dithiolan-2-ylidene]-,(E)-;Astat;153222-93-6
Categories:
Active Pharmaceutical Ingredients > Synthetic Anti-infective Drugs

Description

Light-Yellow CrystalsLanoconazole is a potent antifungal imidazole launched in Japan for the treatment of dermal mycoses. Lanoconazole is reported to be an inhibitor of ergosterol biosynthesis thus altering the ultra structure of the cell wall. It exhibits potent antifungal activity against a wide range of pathogenic fungi including yeast, dermatophytes, dermatiaceous fungi, dimorphic fungi, Aspergihs spp. Penici//ium spp., and Candida spp., being particularly active against Trichophyton s

Lanoconazole is a conazole antifungal drug and an imidazole antifungal drug.

Lanoconazole Basic Attributes

Molecular Weight：

319.83

Exact Mass：

319.83

EC Number：

1312995-182-4

DSSTox ID：

DTXSID6046428

Characteristics

PSA：

92.2

XLogP3：

3.38

Appearance：

Light-Yellow Crystals

Density：

1.43±0.1 g/cm3(Predicted)

Melting Point：

141.5 °C

Boiling Point：

477.6±55.0 °C(Predicted)

Flash Point：

242.6±31.5 °C

Refractive Index：

1.725

Storage Conditions：

2-8°C

Vapor Pressure：

0mmHg at 25°C

Toxicity：

LD50 in male, female mice, rats (mg/kg): 3224, 2715, 993, 652 orally; 2158, 1743, 1655, 2596 i.p.; >5000 both species s.c.; LD50 dermally in rats: >5000 mg/kg (Munt)

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

RTECS Number：

NI3393500

Marks：

Precautionary statement(s)：

P264, P270, P301+P312, P330, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory.

Drug Information

MeSH Entry Terms：

(4-(2-chlorophenyl)-1,3-dithiolan-2-ylidene)-1-imidazolylacetonitrile

Lanoconazole Use and Manufacturing

Antifungal

Computed Properties

Molecular Weight:319.8
XLogP3:3.3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:319.0004674
Monoisotopic Mass:319.0004674
Topological Polar Surface Area:92.2
Heavy Atom Count:20
Complexity:445
Undefined Atom Stereocenter Count:1
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Potassium hydroxide

Dimethylformamide

Recommended Suppliers of Lanoconazole

Shandong Airuike Chemical Co., Ltd. Contact Supplier

CN
3 YRS

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Lanoconazole cas 101530-10-3

CAS No.: 101530-10-3

Grade: Analytical Reagent

Content: 99%

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