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Clinafloxacin

Clinafloxacin structure

CAS No:
105956-97-6
Formula:
C17H17ClFN3O3
Chemical Name:
Clinafloxacin
Synonyms:
3-Quinolinecarboxylic acid,7-(3-amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-;7-(3-Amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid;PD 127391;Clinafloxacin;117404-52-1;1801421-57-7;1802317-14-1
Categories:
Active Pharmaceutical Ingredients > Synthetic Anti-infective Drugs

Description

Clinafloxacin(PD-127391) is a fluoroquinolone antibiotic.Target: AntibacterialClinafloxacin is a broad-spectrum antibiotic of the quinolone carboxylic acid category currently in development for intravenous and oral therapy of serious infections [1]. Clinafloxacin is a novel fluoroquinolone with potent broad-spectrum in vitro activity against gram-positive, gram-negative, and anaerobic pathogens. Clinafloxacin is highly active against S. pneumoniae 7785 (MIC, 0.125 μg/mL), and neither gyr

7-(3-amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-3-quinolinecarboxylic acid is a member of quinolines.|Clinafloxacin is a fluoroquinolone antibacterial currently under research. It has been proven to present good antibiotic properties. However, its approval and release have been halted due to the presence of serious side effects.

Clinafloxacin Basic Attributes

Molecular Weight：

365.79

Exact Mass：

365.79

HScode：

2933990090

Characteristics

PSA：

86.9

XLogP3：

3.12980

Appearance：

White to light yellow crystalline powder.

Density：

1.573±0.06 g/cm3(Predicted)

Melting Point：

253-258 °C (decomp)

Boiling Point：

592.3±50.0 °C(Predicted)

Flash Point：

312ºC

Refractive Index：

1.684

Water Solubility：

>54.9 [ug/mL]

Storage Conditions：

2-8°C

Vapor Pressure：

7.14E-15mmHg at 25°C

Safety Information

Transport codes：

NONH for all modes of transport

hazard class code：

36/37/38-63

safety instructions：

26-36-36/37

RTECS Number：

VB1800600

Marks：

Xi,Xn

Precautionary statement(s)：

P281

Hazard Statements：

H361d

Drug Information

MeSH：

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)|Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II. (See all compounds classified as Topoisomerase II Inhibitors.)

MeSH Entry Terms：

7-(3-amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

Clinafloxacin Use and Manufacturing

Antibacterial.

Computed Properties

Molecular Weight:365.8
XLogP3:0.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:3
Exact Mass:365.0942473
Monoisotopic Mass:365.0942473
Topological Polar Surface Area:86.9
Heavy Atom Count:25
Complexity:626
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Clinafloxacin

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

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Clinafloxacin

CAS No.: 105956-97-6

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Shandong Airuike Chemical Co., Ltd. Contact Supplier

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Clinafloxacin 105956-97-6

CAS No.: 105956-97-6

Grade: Pharmaceutical Grade

Content: 99%

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