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Orbifloxacin

Orbifloxacin structure

CAS No:
113617-63-3
Formula:
C19H20F3N3O3
Chemical Name:
Orbifloxacin
Synonyms:
3-Quinolinecarboxylic acid,1-cyclopropyl-7-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-5,6,8-trifluoro-1,4-dihydro-4-oxo-,rel-;3-Quinolinecarboxylic acid,1-cyclopropyl-7-(3,5-dimethyl-1-piperazinyl)-5,6,8-trifluoro-1,4-dihydro-4-oxo-,cis-;rel-1-Cyclopropyl-7-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-5,6,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid;Orbifloxacin;CP 104354;Orbax
Categories:
Active Pharmaceutical Ingredients > Synthetic Anti-infective Drugs

Description

Orbifloxacin is a synthetic broad-spectrum fluoroquinolone antibiotic which is approved for use in dogs.

Orbifloxacin is a fluoroquinolone antibiotic. It is marketed by Schering-Plough Animal Health and approved for certain infections in dogs.

Orbifloxacin Basic Attributes

Molecular Weight：

395.38

Exact Mass：

395.38

UNII：

660932TPY6

NSC Number：

758614

DSSTox ID：

DTXSID7046201

ATC Code：

QS02CA91

HScode：

29339900

Characteristics

PSA：

72.9

XLogP3：

2.37

Density：

1.436±0.06 g/cm3(Predicted)

Melting Point：

257-258 °C (decomp)

Boiling Point：

590.7±50.0 °C(Predicted)

Flash Point：

311.1±30.1 °C

Refractive Index：

1.588

Vapor Pressure：

8.43E-15mmHg at 25°C

Collision Cross Section：

196.7 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]|199.5 Å² [M+H]+ [CCS Type: TW, Method: calibrated with Waters Major Mix]|206.1 Å² [M+Na]+ [CCS Type: TW, Method: calibrated with Waters Major Mix]

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

safety instructions：

24/25

Precautionary statement(s)：

P201, P202, P281, P308+P313, P405, P501

Hazard Statements：

H361

Drug Information

Drug Indication：

Treatment of acute otitis externa and acute exacerbations of recurrent otitis externa, associated with bacteria susceptible to orbifloxacin and fungi susceptible to posaconazole, in particular Malassezia pachydermatis.

MeSH Entry Terms：

orbifloxacin

Orbifloxacin Use and Manufacturing

Uses

Orbifloxacin is a fluoroquinolone antibiotic used in veterinary medicine, mainly for the treatment of staphylococcal infections in dogs.

Use Classification：

Veterinary drugs -> Posatex -> EMA Drug Category|Otologicals -> Veterinary pharmacotherapeutic group|Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients

Computed Properties

Molecular Weight:395.4
XLogP3:0.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:3
Exact Mass:395.14567599
Monoisotopic Mass:395.14567599
Topological Polar Surface Area:72.9
Heavy Atom Count:28
Complexity:691
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Orbifloxacin

CAS No.: 113617-63-3

Content: 99.00%

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