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Nadifloxacin

Nadifloxacin structure

CAS No:
124858-35-1
Formula:
C19H21FN2O4
Chemical Name:
Nadifloxacin
Synonyms:
1H,5H-Benzo[ij]quinolizine-2-carboxylic acid,9-fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidinyl)-5-methyl-1-oxo-;1H,5H-Benzo[ij]quinolizine-2-carboxylic acid,9-fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidinyl)-5-methyl-1-oxo-,(±)-;9-Fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidinyl)-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid;OPC 7251;Nadifloxacin;Jinofloxacin;Nadixa;9-Fluoro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid;Nadibact;81962-84-7
Categories:
Active Pharmaceutical Ingredients > Synthetic Anti-infective Drugs

Description

Off-White Crystalline SolidNadifloxacin, one of the three new fluoroquinolone antibiotics launched in 1993 is indicated for topical treatment of acne vulgaris and other skin infections. Nadifloxacin has a potent and broad spectrum of activity against aerobic Gram-positive and -negative bacteria and against anaerobic bacteria. It produces significant improvement in patients with Propionibacterium acnes infection and does not appear to cause cross-resistance to other antibiotic agents. Its p

Nadifloxacin is a pyridoquinoline, a hydroxypiperidine, a heteroarylpiperidine and a quinolone antibiotic. It has a role as an antibacterial drug.|Nadifloxacin has been used in trials studying the treatment of Acne Vulgaris.

Nadifloxacin Basic Attributes

Molecular Weight：

360.38

Exact Mass：

360.38

EC Number：

1533716-785-6

NSC Number：

759622

DSSTox ID：

DTXSID5046483

ATC Code：

D - Dermatologicals

Characteristics

PSA：

81.1

XLogP3：

2.9

Appearance：

off-white crystalline solid

Density：

1.46±0.1 g/cm3(Predicted)

Melting Point：

245-247 °C (decomp)

Boiling Point：

624.9±55.0 °C(Predicted)

Flash Point：

331.7±31.5 °C

Refractive Index：

1.669

Storage Conditions：

-20°C Freezer

Vapor Pressure：

1.77E-16mmHg at 25°C

Toxicity：

LD50 male, female mice and rats (mg/kg): 376.5, 420.6, 225.7, 240.5 i.v. (Hashimoto)

Safety Information

Transport codes：

NONH for all modes of transport

Precautionary statement(s)：

P201, P260, P263, P264, P270, P308+P313, P314, P501

Hazard Statements：

H362

Drug Information

MeSH：

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)|Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II. (See all compounds classified as Topoisomerase II Inhibitors.)

MeSH Entry Terms：

9-fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidyl)-5-methyl-1-oxo-1H,5H-benzo(i,j)quinolizine-2-carboxylic acid

Nadifloxacin Use and Manufacturing

Calcium salt of polyacrylic acid crosslinked with divinyl glycol

Computed Properties

Molecular Weight:360.4
XLogP3:2.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:2
Exact Mass:360.14853532
Monoisotopic Mass:360.14853532
Topological Polar Surface Area:81.1
Heavy Atom Count:26
Complexity:631
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Not described in detail

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

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Registered Holders

Tianjin Weijie Pharmaceutical Co., Ltd.

China
Active
Hunan Zonwe Pharm Co., Ltd.

China
Active
Yangtze River Pharmaceutical Group Jiangsu HaiCi Biological Pharmaceutical Co., Ltd.

China
Active

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CAS No.: 124858-35-1

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CAS No.: 124858-35-1

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