 Home > Encyclopedia > Gossypol acetic acid

Gossypol acetic acid

Gossypol acetic acid structure

CAS No:
12542-36-8
Chemical Name:
Gossypol acetic acid
Synonyms:
Gossypol acetic acid;104257-14-9
Categories:
Active Pharmaceutical Ingredients > Hormones and the Endocrine System

Description

Gossypol, a natural product isolated from cottonseeds and roots, binds to Bcl-xL protein and Bcl-2 protein with Kis of 0.5-0.6 μM and 0.2-0.3 mM, respectively.

R-(-)-Gossypol Acetic Acid is the orally bioavailable solvate of the R-(-) enantiomer of gossypol and acetic acid with potential antineoplastic activity. As a BH3 mimetic, R-(-)-gossypol binds to the hydrophobic surface binding groove BH3 of the anti-apoptotic proteins Bcl-2 and Bcl-xL, blocking their heterodimerization with pro-apoptotic members of the Bcl-2 family of proteins such as Bad, Bid, and Bim; this may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. Racemic gossypol is a polyphenolic compound isolated from cottonseed.

Gossypol acetic acid Basic Attributes

Molecular Weight：

578.61

Exact Mass：

578.215210

EC Number：

1806241-263-5

NSC Number：

727858|19048

NCI Thesaurus Code：

C78348

HScode：

29153900

Characteristics

PSA：

193

XLogP3：

6.47310

Appearance：

Yellow crystal powder

Melting Point：

164-168°C

Boiling Point：

707.9ºC at 760 mmHg

Flash Point：

395.9ºC

Water Solubility：

Soluble in acetone or methanol at 5mg/ml

Storage Conditions：

−20°C

Vapor Pressure：

1.05E-20mmHg at 25°C

Toxicity：

Oral-Mouse LD50: 3000 mg/kg

Flammability characteristics：

Flammable, spicy and irritating smoke emitted from the fire

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

22-40

safety instructions：

22-36

RTECS Number：

MD7360000

Marks：

Storage features：

Warehouse low temperature, ventilated, dry

Precautionary statement(s)：

P281

Hazard Statements：

H302-H351

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P264, P270, P281, P301+P312, P308+P313, P330, P405, and P501|Aggregated GHS information provided by 40 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Toxicity class：

moderately toxic

Drug Information

MeSH：

Chemical substances that are destructive to spermatozoa used as topically administered vaginal contraceptives. (See all compounds classified as Spermatocidal Agents.)|Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity. (See all compounds classified as Antineoplastic Agents, Phytogenic.)|Chemical substances or agents with contraceptive activity in females. Use for female contraceptive agents in general or for which there is no specific heading. (See all compounds classified as Contraceptive Agents, Female.)

MeSH Entry Terms：

AT 101

Computed Properties

Molecular Weight:578.6
Hydrogen Bond Donor Count:7
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:5
Exact Mass:578.21519728
Monoisotopic Mass:578.21519728
Topological Polar Surface Area:193
Heavy Atom Count:42
Complexity:811
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Extract from the above information

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Gossypol acetate

Gossypol Potassium Chloride Vitamin B Capsules
Ingredients	This product is a compound preparation, and its components are: each tablet contains 20 mg of gossypol acetate (C32H34O10), 250 mg of potassium chloride, 10 mg of vitamin B1, and 10 mg of vitamin B6, and the auxiliary material is starch.
Indication	Not yet clear.
Specifications	Compound
Manufacturer	Jilin Changbai Mountain Pharmaceutical Group Co., Ltd.

Compound Gossypol Acetate Tablets
Ingredients	This product is a compound preparation, which consists of: gossypol acetate, potassium chloride, vitamin B1, and vitamin B6.
Indication	Not yet clear.
Specifications	Each tablet contains 20 mg of gossypol acetate
Manufacturer	Xi'an Beifang Medicine Co., Ltd.

See More Related Drugs

Registered Holders

Xi'an Beifang Medicine Co., Ltd.

China
Active
Shaanxi Panlong Pharmaceutical Group Limited By Share Ltd

China
Active

Recommended Suppliers of Gossypol acetic acid

Xiamen Eagle Chemical Corporation Contact Supplier

CN
2 YRS

Business licensed

Trader Supplier of Dimethyl sufoxide

Gossypol acetate

Unit Price: $1.1 /KG EXW

CAS No.: 12542-36-8

Grade: top

Content: 99%

Inquiry
Hangzhou KieRay Chem Co.,LTD Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of fine chemicals,pharmaceutical materials

Gossypol-acetic acid

CAS No.: 12542-36-8

Grade: industrial Grade

Content: 98%

Inquiry
Beton Nutrition Corporation Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of olive leaf extract,ginger extract,ginseng extract,Black garlic extract,Echinacea purpurea extract,Horse Chestnut Extract,Pueraria extract,Andrographis Extract,citrus aurantium extract,quercetin,Rutin,chlorogenic acid,Curcumin,Apigenin

Acetate gossypol 12542-36-8

CAS No.: 12542-36-8

Content: 98%

Inquiry