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Porcine Insulin

Porcine Insulin structure

CAS No:
12584-58-6
Formula:
C256H381N65O76S6
Chemical Name:
Porcine Insulin
Synonyms:
8a-l-threonine-10a-l-isoleucine-insulin(ox;insulin(dog);insulin(pig);insulin(spermwhale);insulin,neutral;insulinprocine;neutralinsulin;Insulin from porcine pancreas, ≥27 USP units/mg(HPLC)
Categories:
Active Pharmaceutical Ingredients > Hormones and the Endocrine System

Description

White or almost white powder

Porcine Insulin is a double-chain protein with a molecular mass of 5778, containing 51 amino acids (A-21 and B-30 chains) connected by a disulfide bond. Porcine Insulin has a high degree of similarity to human insulin, differing only in the 30th amino acid. porcine Insulin regulates the uptake, utilisation and storage of glucose, amino acids and fatty acids in cells and inhibits the breakdown of glycogen, proteins and lipids. Therefore, it is used to control hyperglycaemia in diabetic patients.

Porcine Insulin Basic Attributes

Molecular Weight：

5777.54

Exact Mass：

5775.634

EC Number：

235-703-3

Color/Form：

White to Off-White

HScode：

2937120000

Characteristics

PSA：

2430

XLogP3：

-12.5

Appearance：

powder

Water Solubility：

H2O: Slightly soluble ;It can be solubilized in dilute acetic or hydrochloric acid, pH 2-3.

Storage Conditions：

−20°C

Critical Temperature & Pressure：

-20°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

safety instructions：

22-24/25

RTECS Number：

NM8895000

Porcine Insulin Use and Manufacturing

Hormone; treatment of diabetes mellitus.

Porcine Insulin, from porcine pancreas, is used in the determination of the beta-cell reserve during glucose tolerance test or after a carbohydrate rich meal, as a guide for the instauration of insulin therapy, contribution to the diagnosis of insulin and non-insulin-dependent diabetes, characterisation and follow-up of states of glucose intolerance, diagnosis and study of cases of insulin resistance, diagnosis of insulinoma and other causes of hypoglycemia.

Computed Properties

Molecular Weight:5778
XLogP3:-12.5
Hydrogen Bond Donor Count:77
Hydrogen Bond Acceptor Count:88
Rotatable Bond Count:178
Exact Mass:5775.6337952
Monoisotopic Mass:5773.6270855
Topological Polar Surface Area:2430
Heavy Atom Count:403
Complexity:14500
Defined Atom Stereocenter Count:51
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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