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Lamivudine

Lamivudine structure

CAS No:
134678-17-4
Formula:
C8H11N3O3S
Chemical Name:
Lamivudine
Synonyms:
2(1H)-Pyrimidinone,4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-;2(1H)-Pyrimidinone,4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-,(2R-cis)-;1,3-Oxathiolane,2(1H)-pyrimidinone deriv.;4-Amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone;(-)-BCH 189;GR 109714X;Lamivudine;BCH 189,(-)-;(-)-2′-Deoxy-3′-thiacytidine;β-L-3′-Thia-2′,3′-dideoxycytidine;Epivir;Zeffix;Heptovir;Epivir HBV;L-SddC;Zefix;Hepitec;β-L-2′,3′-Dideoxy-3′-thiacytidine;3TC;Lamivir;Heptodin;Virolam;2-Hydroxymethyl-5-(cytosin-1-yl)-1,3-oxathiolane;cis(-)-2-Hydroxymethyl-5-(cytosin-1-yl)-1,3-oxathiolane;Lamidine;29: PN: WO2016077321 SEQID: 29 claimed sequence;Hiviral;480434-79-5;1117764-41-6
Categories:
Active Pharmaceutical Ingredients > Synthetic Anti-infective Drugs

Description

Lamivudine is a nucleoside reverse transcriptase inhibitors?(NRTIs). Lamivudine can inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of hepatitis B virus.

Lamivudine Basic Attributes

Molecular Weight：

229.26

Exact Mass：

229.26

EC Number：

1806241-263-5

NSC Number：

760061|620753

DSSTox ID：

DTXSID10274412

HScode：

2938901000

Characteristics

PSA：

113

XLogP3：

-0.9

Appearance：

white to beige

Density：

1.7±0.1 g/cm3

Melting Point：

160-162 °C

Boiling Point：

475.4°C at 760 mmHg

Flash Point：

9℃

Refractive Index：

-142 ° (C=1, MeOH)

Water Solubility：

70g/L(temperature not stated)

Storage Conditions：

Freezer

Vapor Pressure：

8.3X10-16 mm Hg @ 25 deg C /Estimated/

Specific rotation：

D21 -135° (c = 0.38 in methanol)

Safety Information

Transport codes：

UN1230 - class 3 - PG 2 - Methanol, solution

wgk germany：

hazard class code：

63-36/37/38

safety instructions：

26-36

RTECS Number：

UW7361333

Precautionary statement(s)：

P281

Hazard Statements：

H361

Lamivudine Use and Manufacturing

A reverse transcriptase inhibitor. Antiviral.

Computed Properties

Molecular Weight:229.26
XLogP3:-0.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:229.05211239
Monoisotopic Mass:229.05211239
Topological Polar Surface Area:113
Heavy Atom Count:15
Complexity:331
Undefined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Salicylic acid

Drug Function and Efficacy

Lamivudine is a nucleoside antiviral drug. It has a strong inhibitory effect on hepatitis B virus (HBV) in vitro and in experimentally infected animals. Lamivudine can be metabolized in HBV-infected cells and normal cells to produce lamivudine triphosphate, which is the active form of lamivudine and is both an inhibitor of HBV polymerase and a substrate of this polymerase. Lamivudine triphosphate penetrates into the viral DNA chain and blocks the synthesis of viral DNA. Lamivudine triphosphate does not interfere with the metabolism of deoxynucleosides in normal cells. It has a weak inhibitory effect on mammalian DNA polymerase α and β and has almost no effect on the DNA content of mammalian cells. Lamivudine has no obvious toxicity to the structure, DNA content and function of mitochondria. The results of serum HBVDNA detection in most hepatitis B patients showed that lamivudine can rapidly inhibit HBV replication, and its inhibitory effect lasts throughout the treatment process, while reducing serum aminotransferase to normal. Long-term use can significantly improve liver necrosis and inflammatory changes, and reduce or prevent the progression of liver fibrosis.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Lamivudine Tablets
Ingredients	The main ingredient of this product is lamivudine.
Indication	1. When lamivudine is used simultaneously with drugs with the same excretion mechanism (such as trimethoprim, sulfamethoxazole), the blood concentration of lamivudine can increase by 40%, which has no clinical significance, but patients with renal impairment should pay attention. 2. When used in combination with zidovudine, the latter's peak blood concentration (Cmax) can be increased, but it does not affect the elimination and area under the drug-time curve of the two. Please refer to the inner package insert for details.
Specifications	0.3g
Manufacturer	Fujian Cosunter Pharmaceutical Co., Ltd.

Lamivudine oral solution
Ingredients	Lamivudine.
Indication	1. When lamivudine is used simultaneously with drugs with the same excretion mechanism (such as trimethoprim, sulfamethoxazole), the blood concentration of lamivudine can increase by 40%, which has no clinical significance, but patients with renal impairment should pay attention. 2. Combination with zidovudine can increase the latter's peak blood concentration (Cmax), but does not affect the elimination and area under the drug-time curve of both.
Specifications	240 ml: 2.4 g

Lamivudine Tablets
Indication	1. When lamivudine is used simultaneously with drugs with the same excretion mechanism (such as trimethoprim, sulfamethoxazole), the blood concentration of lamivudine can increase by 40%, which has no clinical significance, but patients with renal impairment should pay attention. 2. When used in combination with zidovudine, the latter's peak blood concentration (Cmax) can be increased, but it does not affect the elimination and area under the drug-time curve of the two.

Lamivudine Tablets

Indication

1. When lamivudine is used simultaneously with drugs with the same excretion mechanism (such as trimethoprim, sulfamethoxazole), the blood concentration of lamivudine can increase by 40%, which has no clinical significance, but patients with renal impairment should pay attention. 2. When used in combination with zidovudine, the latter's peak blood concentration (Cmax) can be increased, but it does not affect the elimination and area under the drug-time curve of the two.

See More Related Drugs

Registered Holders

ARENE LIFE SCIENCES PRIVATE LTD

United States
Active
LAURUS LABS LTD

United States
Active
MATRIX PHARMACORP PRIVATE LTD

United States
Active

See More Registered Holders

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