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Ozagrel sodium

Ozagrel sodium structure

CAS No:
189224-26-8
Formula:
C13H11N2NaO2
Chemical Name:
Ozagrel sodium
Synonyms:
OZAGREL SODIUM;(2E)-3-[4-(1H-Imidazol-1-ylmethyl)phenyl]-2-propenoic acid sodium salt;(E)-3-[4-(1H-Imidazol-1-ylmethyl)phenyl]acrylic acid sodium salt;Athrombone;D01684;Ozagrel sodium (jan);Ozapen;Ozapen (tn)
Categories:
Active Pharmaceutical Ingredients > Blood System Drugs

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Description

White powder

Ozagrel sodium Basic Attributes

Molecular Weight：

250.23

Exact Mass：

250.071823

EC Number：

1806241-263-5

UNII：

4X5577N3ET

DSSTox ID：

DTXSID50172327

Characteristics

PSA：

XLogP3：

0.69450

Boiling Point：

468ºC at 760 mmHg

Flash Point：

236.8ºC

Drug Information

MeSH：

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)|Fibrinolysin or agents that convert plasminogen to FIBRINOLYSIN. (See all compounds classified as Fibrinolytic Agents.)|Drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists. Classical antihistaminics block the histamine H1 receptors only. (See all compounds classified as Histamine Antagonists.)

MeSH Entry Terms：

3-(4-(1H-imidazol-1-ylmethyl)phenyl)-2-propenoic acid

Computed Properties

Molecular Weight:250.23
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:250.07182188
Monoisotopic Mass:250.07182188
Topological Polar Surface Area:58
Heavy Atom Count:18
Complexity:289
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

This product is a thromboxane synthetase inhibitor that can inhibit the production of TXA2, thus having the effects of anti-platelet aggregation and vasodilation. Animal experiments have shown that intravenous administration can reduce plasma TXB2 levels and the Keto-PGF12/TXB2 ratio, inhibit platelet aggregation caused by different inducers, and prevent cerebral infarction caused by the middle cerebral artery in rats.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Ozagrel Sodium for Injection
Ingredients	Ozagrel sodium.
Indication	Avoid mixing with calcium-containing infusions.
Specifications	40mg
Manufacturer	Eisai Liaoning Pharmaciutical Co., Ltd.

Ozagrel Sodium for Injection
Ingredients	Ozagrel sodium.
Indication	Avoid mixing with calcium-containing infusions.
Specifications	40mg (as ozagrel sodium)
Manufacturer	Hainan Lingkang Pharmaceutical Co., Ltd.

Ozagrel Sodium for Injection
Ingredients	Ozagrel sodium.
Indication	Avoid mixing with calcium-containing infusions.
Specifications	40mg (as ozagrel sodium)
Manufacturer	Zhejiang Yatai Pharmaceutical Co., Ltd.

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Registered Holders

塩野フィネス株式会社

Japan
Active
ERREGIERRE SPA

Italy
Active
Shandong Chenghuishuangda Pharmaceutical Co., Ltd.

China
Active

See More Registered Holders

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