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Pinaverium bromide

Pinaverium bromide structure

CAS No:
53251-94-8
Formula:
C26H41BrNO4.Br
Chemical Name:
Pinaverium bromide
Synonyms:
Morpholinium,4-[(2-bromo-4,5-dimethoxyphenyl)methyl]-4-[2-[2-(6,6-dimethylbicyclo[3.1.1]hept-2-yl)ethoxy]ethyl]-,bromide (1:1);Morpholinium,4-[(2-bromo-4,5-dimethoxyphenyl)methyl]-4-[2-[2-(6,6-dimethylbicyclo[3.1.1]hept-2-yl)ethoxy]ethyl]-,bromide;Pinaverium bromide;Dicetel;LAT 1717;L-Pinaverium bromide;Eldicet
Categories:
Active Pharmaceutical Ingredients > Anesthetic Agents

Description

Pinaverium bromide is an L-type calcium channel blocker with selectivity for the gastrointestinal tract, effectively relieves pain, diarrhea and intestinal discomfort, provides good therapeutic efficacies without significant adverse effects on Irritable bowel syndrome (IBS) patients[1].

Pinaverium Bromide is an orally available bromide salt form of pinaverium, a calcium channel blocker (CCB) with antispasmodic activity. Upon oral administration, pinaverium blocks the voltage-dependent calcium channels and inhibits calcium ion influx into the smooth muscle cells located in the gastrointestinal (GI) tract. This prevents smooth muscle contraction and relaxes the GI tract. In addition, pinaverium may both reduce bowel uptake of and facilitate the function of locally active, co-administered drugs.

Pinaverium bromide Basic Attributes

Molecular Weight：

591.42

Exact Mass：

589.140198

EC Number：

258-450-0

DSSTox ID：

DTXSID2048614

NCI Thesaurus Code：

C116775

Characteristics

PSA：

36.9

XLogP3：

2.25510

Appearance：

white crystalline powder

Melting Point：

181 °C

Storage Conditions：

-20°C Freezer

Toxicity：

LD50 in mice (mg/kg): 1400 orally; 66 i.v. (Baronnet, 1974); LD50 i.v. in mice: 37 ±2.4 mg/kg (Baronnet et al.)

Safety Information

Precautionary statement(s)：

P264, P270, P273, P301+P312, P330, P391, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P273, P301+P312, P330, P391, and P501|Aggregated GHS information provided by 47 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

A class of drugs that act by selective inhibition of calcium influx through cellular membranes. (See all compounds classified as Calcium Channel Blockers.)|Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS. (See all compounds classified as Parasympatholytics.)

MeSH Entry Terms：

4-(6-bromoveratryl)-4-(2-(2-(6,6-dimethyl-2-norpinyl)ethoxy)ethyl)morpholinium bromide

Pinaverium bromide Use and Manufacturing

Spasmolytic agent with low incidence of anticholinergic effects. Antispasmodic

Computed Properties

Molecular Weight:591.4
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:10
Exact Mass:591.13818
Monoisotopic Mass:589.14023
Topological Polar Surface Area:36.9
Heavy Atom Count:33
Complexity:596
Undefined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Extract from the above information

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Pinaverium Bromide Tablets
Ingredients	The main ingredient of this product is pinaverium bromide.
Specifications	50mg*15 tablets/box

Pinaverium Bromide

Pinaverium Bromide
Specifications	API

See More Related Drugs

Registered Holders

Luzhou Kereide Pharmaceutical Co., Ltd.

China
Active
JUBILANT BIOSYS LTD

United States
Active
Abbott Laboratories Trading (Shanghai) Co., Ltd.

China
Active

See More Registered Holders

Recommended Suppliers of Pinaverium bromide

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

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Pinaverium bromide

CAS No.: 53251-94-8

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