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Carboprost tromethamine

Carboprost tromethamine structure

CAS No:
58551-69-2
Formula:
C21H36O5.C4H11NO3
Chemical Name:
Carboprost tromethamine
Synonyms:
Prosta-5,13-dien-1-oic acid,9,11,15-trihydroxy-15-methyl-,(5Z,9α,11α,13E,15S)-,compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1);1,3-Propanediol,2-amino-2-(hydroxymethyl)-,(5Z,9α,11α,13E,15S)-9,11,15-trihydroxy-15-methylprosta-5,13-dien-1-oate (salt);Carboprost tromethamine;Prostinfenem;Hemabate;Prostodin;U 32921E;Carboprost trometamol;Carboprost tromethamine Salt;Prostin 15M
Categories:
Active Pharmaceutical Ingredients > Hormones and the Endocrine System

Description

White or almost white powder.

Carboprost Tromethamine is the tromethamine salt of the (15S)-15 methyl analogue of naturally occurring prostaglandin F2 alpha (PGF2 alpha) with oxytocic activity. Mimicking endogenous PGF2 alpha, carboprost activates prostaglandin F receptor, a G-protein coupled receptor, on smooth muscle cells, thereby resulting in smooth muscle contractions. When administered intramuscularly on gravid subjects, this agent induces myometrium contractions, thereby initiating luteolysis and consequently parturition. Furthermore, carboprost's action on vascular smooth muscle and gastrointestinal tract sphincters leads to raised blood pressure and induces vomiting or diarrhea, respectively.

Carboprost tromethamine Basic Attributes

Molecular Weight：

489.64

Exact Mass：

489.330170

UNII：

U4526F86FJ

NCI Thesaurus Code：

C47433

HScode：

2937500000

Characteristics

PSA：

184.70000

XLogP3：

1.79410

Density：

1.153g/cm3

Boiling Point：

536.6ºC at 760 mmHg

Flash Point：

292.4ºC

Safety Information

Transport codes：

NONH for all modes of transport

GHS Classification：

|Danger|H335 (18.18%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]|P201, P202, P261, P271, P281, P304+P340, P308+P313, P312, P403+P233, P405, and P501|Aggregated GHS information provided by 33 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Drugs that stimulate contraction of the myometrium. They are used to induce LABOR, OBSTETRIC at term, to prevent or control postpartum or postabortion hemorrhage, and to assess fetal status in high risk pregnancies. They may also be used alone or with other drugs to induce abortions (ABORTIFACIENTS). Oxytocics used clinically include the neurohypophyseal hormone OXYTOCIN and certain prostaglandins and ergot alkaloids. (From AMA Drug Evaluations, 1994, p1157) (See all compounds classified as Oxytocics.)

MeSH Entry Terms：

15-methylprostaglandin F2alpha-tromethamine

Carboprost tromethamine Use and Manufacturing

Uses

Oxytocic.

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:489.6
Hydrogen Bond Donor Count:8
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:15
Exact Mass:489.33016746
Monoisotopic Mass:489.33016746
Topological Polar Surface Area:185
Heavy Atom Count:34
Complexity:527
Defined Atom Stereocenter Count:5
Defined Bond Stereocenter Count:2
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Not described in detail

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Carboprost Tromethamine
Specifications	API

Carboprost Tromethamine Injection
Specifications	1 ml: 250 micrograms

Carboprost Tromethamine Injection
Ingredients	Main ingredients: Each bottle of 1 ml sterile injection of this product contains carboprost tromethamine equivalent to 250μg of carboprost. Chemical name: 1.2-amino-2-(hydroxymethyl)-1,3-propanediol (5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-3-methyl-1-octenylcyclopentyl}-5-heptenoate 2.7-{(3α,5α-dihydroxy-2β[(3s)-3-hydroxy-3-methyl-trans-1 octenyl]-1α-cyclopentyl}-cis-5-heptenoic acid compound-2-amino-2-(hydroxymethyl)-1,3-propanediol Diol 3.5,13-diene-1-acid, 9,11,15-trihydroxy-15-methyl-, (5Z, -9α, 11α, 13E, 15S) -prostaglandin, 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1) ④ (15S) -15-methyl prostaglandin F2α tromethamine salt chemical structure is: Molecular formula: C25H47NO8 Molecular weight: 489.64 Excipients: Each bottle of sterile injection of this product contains tromethamine, sodium chloride and benzyl alcohol used as a preservative.
Indication	1. This product may enhance the activity of other uterotonic drugs, so it is not recommended to be used in combination with other uterotonic drugs. 2. This product can improve the success rate of anti-early pregnancy when used with testosterone propionate or gestrinone. 3. This product has a synergistic inhibitory effect on spermatogenesis when used in large doses with cottonypol, while a small dose can reduce the inhibitory effect of cottonypol. 4. It has an antagonistic effect when used in combination with non-steroidal anti-inflammatory drugs and is generally not suitable for use. 5. Dextran can inhibit allergic reactions caused by this product.
Specifications	1ml:250μg
Manufacturer	Changzhou Siyao Pharmaceuticals Co., Ltd.

See More Related Drugs

Registered Holders

TIEN (TIANJIN) PHARMACEUTICAL CO LTD

United States
Active
MSN LABORATORIES PRIVATE LTD

United States
Active
EUROAPI Hungary Ltd

United States
Active

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