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Epoprostenol sodium

Epoprostenol sodium structure

CAS No:
61849-14-7
Formula:
C20H32O5.Na
Chemical Name:
Epoprostenol sodium
Synonyms:
Prosta-5,13-dien-1-oic acid,6,9-epoxy-11,15-dihydroxy-,sodium salt (1:1),(5Z,9α,11α,13E,15S)-;Prosta-5,13-dien-1-oic acid,6,9-epoxy-11,15-dihydroxy-,monosodium salt,(5Z,9α,11α,13E,15S)-;Prostacyclin sodium salt;PGI2 sodium salt;Sodium PGI2;PGI2 sodium;Prostacyclin sodium;Sodium prostacyclin;Flolan;Epoprostenol sodium;Veletri;91284-07-0
Categories:
Active Pharmaceutical Ingredients > Hormones and the Endocrine System

Description

Epoprostenol sodium (Prostaglandin I2 (sodium salt)), the synthetic form of the natural prostaglandin derivative prostacyclin (prostaglandin I2), is registered worldwide for the treatment of Pulmonary arterial hypertension (PAH)[1]. Epoprostenol sodium is used in pulmonary hypertension and transplantation as a potent inhibitor of platelet aggregation[2].

Epoprostenol sodium Basic Attributes

Molecular Weight：

374.45

Exact Mass：

374.206909

EC Number：

234-237-8

HScode：

29329900

Characteristics

PSA：

89.82000

XLogP3：

2.07380

Appearance：

white powder

Melting Point：

168-170 °C

Boiling Point：

530.2ºC at 760mmHg

Flash Point：

182.1ºC

Water Solubility：

H2O: 1 mg/mL Hydrolyzes to 6-ketoprostaglandin F1α in aqueous solution.

Storage Conditions：

−20°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

20/21/22

safety instructions：

22-26-36

RTECS Number：

UK8008700

Marks：

Precautionary statement(s)：

P261-P280-P301 + P312 + P330

Hazard Statements：

H302 + H312 + H332

Epoprostenol sodium Use and Manufacturing

An Eicosanoid which prevents the formation of platelet plugs and is an effective vasodilator.

Computed Properties

Molecular Weight:352.5
XLogP3:2.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:10
Exact Mass:352.22497412
Monoisotopic Mass:352.22497412
Topological Polar Surface Area:87
Heavy Atom Count:25
Complexity:485
Undefined Atom Stereocenter Count:5
Undefined Bond Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Prostacyclin sodium salt

CAS No.: 61849-14-7

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cas61849-14-7 Epoprostenol sodium

CAS No.: 61849-14-7

Grade: Pharmaceutical Grade

Content: 99%

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