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DESMOPRESSIN ACETATE

DESMOPRESSIN ACETATE structure

CAS No:
62357-86-2
Formula:
C48H74N14O17S2
Chemical Name:
DESMOPRESSIN ACETATE
Synonyms:
1-(3-mercaptopropanoicacid)-8-d-argininevasopressinmonoacetate(salt),trih;demopressinacetate;kw-8008;stimateinjection;vasopressin,1-(3-mercaptopropanoicacid)-8-d-arginine-,monoacetate(salt),tr;DESMOPRESSIN ACETATE TRIHYDRATE;Desmopressin Acetate (1.91 mg) (COLD SHIPMENT REQUIRED);Mpr-Tyr-Phe-Gln-Asn-Cys-Pro-D-Arg-Gly-NH2 (Disulfide bridge Mpr1-Cys6)
Categories:
Active Pharmaceutical Ingredients > Urinary System Drugs

Description

ChEBI: The trihydrate of the acetic acid salt of desmopressin. An antidiuretic, it increases urine concentration and decreases urine production, and is used to prevent and control excessive thirst, urination, and dehydration caused by injury, surgery, and certain medical conditions. It is also used in the diagnosis and treatment of cranial diabetes insipidus and in tests of renal function.

A synthetic analog of the pituitary hormone, ARGININE VASOPRESSIN. Its action is mediated by the VASOPRESSIN receptor V2. It has prolonged antidiuretic activity, but little pressor effects. It also modulates levels of circulating FACTOR VIII and VON WILLEBRAND FACTOR.

DESMOPRESSIN ACETATE Basic Attributes

Molecular Weight：

1183.31

Exact Mass：

1182.48000

DSSTox ID：

DTXSID4046864

HScode：

2937190090

Characteristics

PSA：

551.00000

XLogP3：

1.42150

Safety Information

GHS Classification：

|Danger|H314 (94.44%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]|P260, P261, P264, P271, P272, P280, P285, P301+P330+P331, P302+P352, P303+P361+P353, P304+P312, P304+P340, P304+P341, P305+P351+P338, P310, P312, P321, P333+P313, P342+P311, P363, P405, and P501|Aggregated GHS information provided by 19 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Agents that reduce the excretion of URINE, most notably the octapeptide VASOPRESSINS. (See all compounds classified as Antidiuretic Agents.)|Agents acting to arrest the flow of blood. Absorbable hemostatics arrest bleeding either by the formation of an artificial clot or by providing a mechanical matrix that facilitates clotting when applied directly to the bleeding surface. These agents function more at the capillary level and are not effective at stemming arterial or venous bleeding under any significant intravascular pressure. (See all compounds classified as Hemostatics.)

MeSH Entry Terms：

1-Deamino-8-D-arginine Vasopressin

DESMOPRESSIN ACETATE Use and Manufacturing

Uses

Antidiuretic.

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:1183.3
Hydrogen Bond Donor Count:17
Hydrogen Bond Acceptor Count:20
Rotatable Bond Count:19
Exact Mass:1182.47977929
Monoisotopic Mass:1182.47977929
Topological Polar Surface Area:529
Heavy Atom Count:81
Complexity:2070
Undefined Atom Stereocenter Count:7
Covalently-Bonded Unit Count:5
Compound Is Canonicalized:Yes

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Desmopressin acetate

CAS No.: 62357-86-2

Content: 99.00%

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