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AROTINOLOL HCL

AROTINOLOL HCL structure

CAS No:
68377-91-3
Formula:
C15H22ClN3O2S3
Chemical Name:
AROTINOLOL HCL
Synonyms:
thiazolehcl;2-Thiophenecarboxamide, 5-[2-[[3-[(1,1-dimethylethyl)amino]-2-hydroxypropyl]thio]-4-thiazolyl]-, monohydrochloride;2-Thiophenecarboxamide, 5-[2-[[3-[(1,1-dimethylethyl)amino]-2-hydroxypropyl]thio]-4-thiazolyl]-, monohydrochloride, (+-)-;Almarl;ARL;(+-)-2-(3'-tert-Butylamino-2'-hydroxypropylthio)-4-(5'-carbamoyl-2'-thienyl)thiazole HCl;Acemail;Anasirol
Categories:
Organic Chemistry > Amides

Description

Arotinolol hydrochloride is an aromatic amide and a member of thiophenes.

Arotinolol hydrochloride i s a β-adrenergic blocker with weak α-antagonistic properties, useful in the treatment of hypertension.

AROTINOLOL HCL Basic Attributes

Molecular Weight：

408

Exact Mass：

407.056274

DSSTox ID：

DTXSID1046849

Color/Form：

White to Orange to Green

HScode：

2934.99.3000

Characteristics

PSA：

170

XLogP3：

4.70480

Density：

1.35g/cm3

Melting Point：

234-235.5° (dec)

Boiling Point：

599.8ºC at 760mmHg

Flash Point：

316.6ºC

Water Solubility：

Practically insoluble in water

Toxicity：

LD50 in mice (mg/kg): 86 i.v., >360 i.p., >5000 orally (Hara)

Flammability characteristics：

Thermal decomposition releases toxic nitrogen oxides, sulfur oxides and hydrogen chloride fumes

Critical Temperature & Pressure：

Keep in dark place,Inert atmosphere,Room temperature

Safety Information

Packing level：

III

Hazard category：

6.1

Transport codes：

UN 2811 6.1/PG III

RTECS Number：

XM8301000

Storage features：

The warehouse is ventilated, low temperature and dry; stored separately from food raw materials

Precautionary statement(s)：

P264, P270, P301+P310, P321, P330, P405, P501

Hazard Statements：

H301

RIDADR：

UN 2811 6.1/PG III

GHS Classification：

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P301+P310, P321, P330, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Toxicity

Toxicity class：

highly toxic

Drug Information

MeSH：

Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. (See all compounds classified as Adrenergic alpha-Antagonists.)|Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety. (See all compounds classified as Adrenergic beta-Antagonists.)

MeSH Entry Terms：

2-(3'-tert-butylamino-2'-hydroxypropylthio)-4-(5'-carbamoyl-2'-thienyl)thiazole hydrochloride

AROTINOLOL HCL Use and Manufacturing

Arotinolol is both and alpha- and beta-adrenoceptor antagonist and is used to treat essential tremors and hypertension.

Computed Properties

Molecular Weight:408.0
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:8
Exact Mass:407.0562682
Monoisotopic Mass:407.0562682
Topological Polar Surface Area:170
Heavy Atom Count:24
Complexity:406
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

This drug has α- and β-receptor blocking effects, with an action ratio of approximately 1:8. This drug has a blood pressure lowering effect caused by β-blocking without increasing peripheral vascular resistance through appropriate α-blocking effects.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Arotinolol Hydrochloride Tablets
Ingredients	Arotinolol Hydrochloride
Indication	The combined use of drugs that have an inhibitory effect on the sympathetic nervous system (such as reserpine) may sometimes cause symptoms of excessive inhibition. The combined use of hypoglycemic drugs may sometimes enhance the hypoglycemic effect. The combined use of calcium antagonists may sometimes enhance each other's effects. Clonidine may enhance the rebound phenomenon after drug withdrawal. The combined use of dipyrrolidone, procainamide, and amarin may cause symptoms of excessive inhibition of cardiac function.
Specifications	10 mg

Arotinolol Hydrochloride Tablets
Ingredients	Arotinolol Hydrochloride
Indication	The combined use of drugs that have an inhibitory effect on the sympathetic nervous system (such as reserpine) may sometimes cause symptoms of excessive inhibition. The combined use of hypoglycemic drugs may sometimes enhance the hypoglycemic effect. The combined use of calcium antagonists may sometimes enhance each other's effects. Clonidine may enhance the rebound phenomenon after drug withdrawal. The combined use of dipyrrolidone, procainamide, and amarin may cause symptoms of excessive inhibition of cardiac function.
Specifications	10 mg

Arotinolol Hydrochloride Tablets
Ingredients	Arotinolol Hydrochloride
Indication	The combined use of drugs that have an inhibitory effect on the sympathetic nervous system (such as reserpine) may sometimes cause symptoms of excessive inhibition. The combined use of hypoglycemic drugs may sometimes enhance the hypoglycemic effect. The combined use of calcium antagonists may sometimes enhance each other's effects. Clonidine may enhance the rebound phenomenon after drug withdrawal. The combined use of dipyrrolidone, procainamide, and amarin may cause symptoms of excessive inhibition of cardiac function.
Specifications	5 mg

See More Related Drugs

Registered Holders

Ningbo Renjian Chemical Phar Maceutical Co., Ltd.

China
Active
Anhui Tingworld Pharmaceutical Co., Ltd.

China
Active
Shi Jiazhuang Great Pharmaceutical Co., Ltd.

China
Active

See More Registered Holders

Recommended Suppliers of AROTINOLOL HCL

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

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Arotinolol hydrochloride

CAS No.: 68377-91-3

Content: 99.00%

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