 Home > Encyclopedia > Acyclovir sodium

Acyclovir sodium

Acyclovir sodium structure

CAS No:
69657-51-8
Formula:
C8H11N5O3.Na
Chemical Name:
Acyclovir sodium
Synonyms:
6H-Purin-6-one,2-amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-,sodium salt (1:1);6H-Purin-6-one,2-amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-,monosodium salt;Acycloguanosine sodium;Sodium acyclovir;Acyclovir sodium;Acyclovir sodium salt
Categories:
Active Pharmaceutical Ingredients > Synthetic Anti-infective Drugs

Description

Acyclovir Sodium is the sodium salt form of acyclovir, a synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2, varicella-zoster virus and other viruses of the herpesvirus family. After conversion in vivo to the active metabolite acyclovir triphosphate by viral thymidine kinase, acyclovir competitively inhibits viral DNA polymerase by incorporating into the growing viral DNA chain and terminating further polymerization.|A GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes.

Acyclovir sodium Basic Attributes

Molecular Weight：

247.19

Exact Mass：

247.06800

EC Number：

1312995-182-4

NCI Thesaurus Code：

C47956

HScode：

2933990090

Characteristics

PSA：

122.14000

XLogP3：

0.09990

Boiling Point：

613.1ºC at 760 mmHg

Toxicity：

Subcutaneous-rat LD50: 650 mg/kg; peritoneal-mouse LD50: 999 mg/kg

Flammability characteristics：

Flammable; burning releases toxic nitrogen oxides and sodium oxide fumes; drug side effects: nausea, vomiting

Safety Information

Storage features：

Treasury is ventilated, low temperature and dry; stored separately from food materials

GHS Classification：

|Warning|H315 (50%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P272, P273, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P333+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Toxicity class：

moderately toxic

Drug Information

MeSH：

Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. (See all compounds classified as Antiviral Agents.)

MeSH Entry Terms：

9-((2-Hydroxyethoxy)methyl)guanine

Acyclovir sodium Use and Manufacturing

Uses

Used as an antiviral intermediate

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:247.19
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:4
Exact Mass:247.06813348
Monoisotopic Mass:247.06813348
Topological Polar Surface Area:122
Heavy Atom Count:17
Complexity:237
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Recommended Suppliers of Acyclovir sodium

Honour Enterprise Company Limited Contact Supplier

CN
4 YRS

Business licensed

Trader Supplier of Semaglutide,Tirzepatide,API,Enzyme

More than 15 years GMP Factory Suppy 99.5% ciclovir sodium Medical Grade CASA69657-51-8

CAS No.: 69657-51-8

Grade: Pharmaceutical Grade

Content: 99.5%

Inquiry
POLY PHARM Contact Supplier

CN
3 YRS

Business licensed Certified factory

Manufactory Supplier of Gadoterate Meglumine,Gadoteridol,Gadobutrol,Iopamidol,iohexol,Ioversol,Ganciclovir sodium,Aciclovir sodium

Aciclovir sodium-

CAS No.: 69657-51-8

Content: 99%

Inquiry