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Limaprost

Limaprost structure

CAS No:
74397-12-9
Formula:
C22H36O5
Chemical Name:
Limaprost
Synonyms:
2-Heptenoic acid,7-[(1R,2R,3R)-3-hydroxy-2-[(1E,3S,5S)-3-hydroxy-5-methyl-1-nonen-1-yl]-5-oxocyclopentyl]-,(2E)-;Prosta-2,13-dien-1-oic acid,11,15-dihydroxy-17,20-dimethyl-9-oxo-,(2E,11α,13E,15S,17S)-;2-Heptenoic acid,7-[(1R,2R,3R)-3-hydroxy-2-[(1E,3S,5S)-3-hydroxy-5-methyl-1-nonenyl]-5-oxocyclopentyl]-,(2E)-;(2E)-7-[(1R,2R,3R)-3-Hydroxy-2-[(1E,3S,5S)-3-hydroxy-5-methyl-1-nonen-1-yl]-5-oxocyclopentyl]-2-heptenoic acid;ONO 1206;OP 1206;17S,20-Dimethyl-trans-Δ2-PGE1;Limaprost;99965-37-4;114868-74-5;114868-76-7;85679-52-3
Categories:
Active Pharmaceutical Ingredients > Hormones and the Endocrine System

Description

Limaprost(OP1206) is a PGE1 analog and potent platelet adhesion inhibitor.Target: OthersLimaprost, an alprostadil (prostaglandin E1) analogue, is a vasodilator that increases blood flow and inhibits platelet aggregation. Limaprost is a n analog of PGE1 with structural modifications intended to give a prolonged half-life and greater potency. It is orally active in both guinea pigs and rats at doses of 100 mg/kg as an inhibitor of ADP and collagen induced platelet aggregation. It is 10-1,0

Limaprost Basic Attributes

Molecular Weight：

380.52

Exact Mass：

380.52

Characteristics

PSA：

94.8

XLogP3：

3.15

Appearance：

crystalline

Density：

1.118

Melting Point：

97-100°

Boiling Point：

550.6±50.0 °C at 760 mmHg

Flash Point：

300.9±26.6 °C

Refractive Index：

1.551

Water Solubility：

DMF: soluble

Storage Conditions：

−20°C

Safety Information

Transport codes：

UN 2811 6.1/PG 2

wgk germany：

hazard class code：

safety instructions：

36/37/39-45

RTECS Number：

UK8362500

Marks：

Precautionary statement(s)：

P264-P301 + P310

Hazard Statements：

H300

Limaprost Use and Manufacturing

Limaprost is an analog of Prostaglandin E1 with structural modifications intended to give it a prolonged half-life and greater potency. Limaprost is used as an antianginal.

Material

Isopropanol

Trifluoroacetic acid

Drug Function and Efficacy

Unspecified

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Limaprost Tablets
Ingredients	The active ingredient is limaprost
Indication	Limaprost inhibits platelet aggregation, and its effect may be enhanced when used in combination with drugs with similar efficacy. Therefore, when used in combination with antiplatelet drugs (such as aspirin, ticlopidine, cilostazol, etc.), thrombolytic drugs (such as urokinase, etc.), and anticoagulants (such as heparin sodium, warfarin, etc.), it may increase the tendency of bleeding. Patients should be carefully observed and the dosage should be adjusted.
Specifications	5µg
Manufacturer	Beijing Tide Pharmaceutical Co., Ltd.

Registered Holders

Beijing Ansenbo Pharmaceutical Technology Co., Ltd.

China
Inactive

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Guide of Limaprost

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Material
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
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Limaprost

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