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Octreotide

Octreotide structure

CAS No:
79517-01-4
Formula:
C49H66N10O10S2
Chemical Name:
Octreotide
Synonyms:
SANDOSTATIN;SMS-201-995;[r-(r*,r*)]-d-phenylalanyl-l-cysteinyl-l-phenylalanyl-d-tryptophyl-l-lysyl-l-threonyl-n-[2-hydroxy-1-(hydroxy-methyl)propyl]-cysteinamide cyclic(2->7)-disulfide;OCTREOTIDE;OCTREOTIDE (SMS 201-995), ACETATE;cyclic(2-7)-disulfide,(r-l-threonyl-n-(2-hydroxy-1-(hydroxymethyl)propyl);d-phenylalanyl-l-cysteinyl-l-phenylalanyl-d-tryptophyl-l-lysyl-l-cysteinamid;r*))-(racetate(salt)
Categories:
Active Pharmaceutical Ingredients > Hormones and the Endocrine System

Description

Octreotide acetate, a long-acting synthetic analog of native somatostatin, inhibits growth hormone, glucagon, and insulin more potently.

Octreotide Basic Attributes

Molecular Weight：

1019.24

Exact Mass：

1018.440481

EC Number：

1308068-626-2

HScode：

2937190000

Characteristics

PSA：

382.82000

XLogP3：

0.77

Appearance：

Colourless to off-white lyophilised solid

Density：

1.4±0.1 g/cm3

Melting Point：

153-156°C

Boiling Point：

1447.2±65.0 °C at 760 mmHg

Flash Point：

829.1±34.3 °C

Refractive Index：

1.673

Water Solubility：

H2O: soluble

Storage Conditions：

−20°C

Toxicity：

Intravenous-rat LD50: 18.1 mg/kg; Intravenous-mouse LD50: 72.3 mg/kg

Flammability characteristics：

Combustible; Fire site decomposes toxic nitrogen oxides, sulfur oxide fumes

Specific rotation：

D20 -42° (c = 0.5 in 95% acetic acid)

PKA：

12.6None

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

Storage features：

Treasury is low temperature, ventilated, dry; stored separately from food raw materials

GHS Classification：

|Warning|H315 (75%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, and P362|Aggregated GHS information provided by 4 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Toxicity class：

highly toxic

Octreotide Use and Manufacturing

natural hormone somatostatin

Computed Properties

Molecular Weight:1139.3
Hydrogen Bond Donor Count:15
Hydrogen Bond Acceptor Count:18
Rotatable Bond Count:17
Exact Mass:1138.48273942
Monoisotopic Mass:1138.48273942
Topological Polar Surface Area:457
Heavy Atom Count:79
Complexity:1780
Defined Atom Stereocenter Count:2
Undefined Atom Stereocenter Count:8
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes

Drug Function and Efficacy

It can inhibit the pathological excessive secretion of growth hormone, thyroid-stimulating hormone, gastrointestinal and pancreatic endocrine hormones; it can selectively reduce the blood flow and pressure of the portal vein and its collateral circulation, and reduce the pressure of varicose veins in the esophagus and gastric fundus; it can inhibit gallbladder emptying and have a therapeutic effect on pancreatic lesions; it can inhibit the secretion of gastric acid and gastrin, and improve the blood supply to the gastric mucosa; it can inhibit gastrointestinal motility.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Octreotide Acetate Injection
Ingredients	Each vial contains the active ingredient octreotide acetate equivalent to 100 μg of octreotide. Excipients include glacial acetic acid, sodium acetate, sodium chloride and water for injection. The chemical name of octreotide acetate is: D-phenylalanine-L-cysteine-L-phenylalanine-D-tryptophan-L-threonine-N-[2-hydroxy-1-(hydroxymethyl)propyl]-L-cysteine (2→7)-disulfide bond compound structure: Molecular formula: C49H66N10O10S2 Molecular weight: 1019.3
Indication	It can reduce the intestinal absorption of cyclosporine and delay the absorption of cimetidine.
Specifications	1 ml: 100 micrograms

Registered Holders

HYBIO PHARMACEUTICAL CO., LTD.

European Union
Active
PolyPeptide Laboratories (Sweden) AB

European Union
Active
CHENGDU SHENGNUO BIOPHARM CO., LTD.

European Union
Active

See More Registered Holders

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