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Ropivacaine mesylate

Ropivacaine mesylate structure

CAS No:
854056-07-8
Formula:
C18H30N2O4S
Chemical Name:
Ropivacaine mesylate
Synonyms:
ROPIVACAINE MESYLATE;(2S)-N-(2,6-Dimethylphenyl)-1-propyl-2-piperidinecarboxamide monomethanesulfonate;Ropivacaine Mesylate API;Ropivacaine mesylate (2S)-N-(2,6-Dimethylphenyl)-1-propyl-2-piperidinecarboxamide monomethanesulfonate;Ropivacaine Mesylate Injection
Categories:
Active Pharmaceutical Ingredients > Anesthetic Agents

Description

Ropivacaine mesylate is an aminoamide compound, effectively blocks neuropathic pain. Ropivacaine mesylate is an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane. Ropivacaine mesylate inhibits pressure-induces lung endothelial hyperpermeability in models of acute hypertension[1][2].

Ropivacaine mesylate Basic Attributes

Molecular Weight：

370.51

Exact Mass：

274.204498

HScode：

2942000000

Characteristics

PSA：

95.1

XLogP3：

3.11

Density：

1.0±0.1 g/cm3

Boiling Point：

410.2±45.0 °C at 760 mmHg

Flash Point：

201.9±28.7 °C

Refractive Index：

1.552

Computed Properties

Molecular Weight:370.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:370.19262862
Monoisotopic Mass:370.19262862
Topological Polar Surface Area:95.1
Heavy Atom Count:25
Complexity:401
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Extracting pharmacological effects from the above information

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Ropivacaine Mesylate for Injection
Specifications	23.8 mg (calculated as C17H26N2O·CH4SO3)
Manufacturer	Cisen Pharmaceutical Co., Ltd.

Ropivacaine Mesylate Sodium Chloride Injection
Specifications	100ml: ropivacaine mesylate 238mg and sodium chloride 0.86g
Manufacturer	Anhu Welman Pharmaceut Icai Cd.ltd

Ropivacaine Mesylate Injection
Ingredients	The main component of this product is ropivacaine mesylate, chemical name is (S)-N-(2,6-dimethylphenyl)-1-propyl-2-piperidinamide methanesulfonate Molecular formula: C17H26N2O.CH3SO3H Molecular weight: 370.51
Indication	Patients receiving other local anesthetics or drugs related to the amide structure should also be treated with caution when ropivacaine injection is used concomitantly because toxic effects can be additive.
Specifications	10ml:23.8mg
Manufacturer	YANGTZE River Pharmaceutical Group Nanjing Pharmaceutical. Co., Ltd.

See More Related Drugs

Registered Holders

Anhu Welman Pharmaceut Icai Cd.ltd

China
Active
STAR Pharmaceutical Pte.ltd

China
Active
Shandong Chenlong Pharmaceutical Co., Ltd.

China
Active

See More Registered Holders

Recommended Suppliers of Ropivacaine mesylate

Henan Lihao Chem Plant Limited Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of PVC resin,pvc paste resin,melamine

High purity Ropivacaine mesylate 99% high quality see COA KANBEI

CAS No.: 854056-07-8

Grade: Industrial Grade

Content: 99%

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