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Ciprofloxacin

Ciprofloxacin structure

CAS No:
85721-33-1
Formula:
C17H18FN3O3
Chemical Name:
Ciprofloxacin
Synonyms:
3-Quinolinecarboxylic acid,1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-;1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid;BAY-q 3939;Ciprofloxacin;Cipro IV;Cipropol;Euciprin;Ciprobay 100;1-Cyclopropyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxo-3-quinoline carboxylic acid;Ciprine;Oftacifox;Catex;Ciprofloxacillin;Ciprofloxacine;Ciprolet;Cipromed;Ciprovet;Ciflafin;Ciprolet DS;Procip;Cyclofloxacin;Ciproxim;Ciproxina;Cunesin;Quinox XR;1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid;Novidate;Cinthocip 500;Ciprodac;Cipronex;Urociproxin;Ciprox;Ciproval;Infu-luxacin;Lipoquin;Pulmaquin;Profloxacin;OTO 201;AuriPro;Otiprio;1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-quinoline-3-carboxylic acid;1-Cyclopropyl-6-fluoro-4-oxo-7-piperazin-4-ium-1-ylquinoline-3-carboxylate;ARD 3150;Inhaled ciprofloxacin ARD 3150;178489-05-9;189257-90-7;1234562-12-9
Categories:
Active Pharmaceutical Ingredients > Inhibitor Drugs

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Description

Ciprofloxacin is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity.

Ciprofloxacin Basic Attributes

Molecular Weight：

331.34

Exact Mass：

331.34

EC Number：

1592732-453-0

HScode：

3004909090

Characteristics

PSA：

72.9

XLogP3：

-1.1

Appearance：

Solid

Density：

1.5±0.1 g/cm3

Melting Point：

225-257 °C (decomp)

Boiling Point：

581.8°C at 760 mmHg

Flash Point：

305.6±30.1 °C

Refractive Index：

1.655

Water Solubility：

soluble in 0.1N HCl at 25mg/ml. Poorly soluble in DMSO

Storage Conditions：

Store at 0-5°C

Vapor Pressure：

2.85X10-13 mm Hg at 25 deg C (est)

PH：

pH range for the 1.0% aqueous concentrates in vials is 3.3 to 3.9; the pH range for the 0.2% ready-for-use infusion solutions is 3.5 to 4.6

PKA：

6.09None

Safety Information

Transport codes：

UN 3077 9 / PGIII

wgk germany：

hazard class code：

36/37/38

safety instructions：

26-36-24/25

RTECS Number：

VB1993800

Marks：

Stability/Shelf Life：

The physical and chemical compatibilities of ciprofloxacin lactate infusion with other commonly used iv admin drugs /was investigated/ Ciprofloxacin lactate injection in a commercially available concn of 2 mg/ml was mixed with 15 iv drugs during a simulated Y-site injection. Of the 15 drugs /examined/ , only heparin, furosemide and teicoplanin were found to be incompatible with ciprofloxacin. /Ciprofloxacin lactate/

Precautionary statement(s)：

P201, P202, P264, P273, P280, P281, P305+P351+P338, P308+P313, P337+P313, P405, P501

Hazard Statements：

H319

Ciprofloxacin Use and Manufacturing

Fluorinated quinolone antibacterial

Computed Properties

Molecular Weight:331.34
XLogP3:-1.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:3
Exact Mass:331.13321961
Monoisotopic Mass:331.13321961
Topological Polar Surface Area:72.9
Heavy Atom Count:24
Complexity:571
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Potassium carbonate

Dimethyl carbonate

Dimethyl sulfoxide

Dimethylformamide

Propionic acid

2,4-Dichlorotoluene

Methyl acrylate

Drug Function and Efficacy

Antibacterial effect

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Ciprofloxacin Tablets
Specifications	0.25g

Ciprofloxacin Lactate for Injection
Ingredients	The content of ciprofloxacin lactate should be calculated as ciprofloxacin (C17H18FN3O3), which should be 90.0% to 110.0% of the labeled amount
Indication	1. Urine alkalinizers can reduce the solubility of this product in urine, leading to crystalluria and nephrotoxicity. 2. When this product is used in combination with theophylline, competitive inhibition of the cytochrome P450 binding site may lead to a significant reduction in the hepatic clearance of theophylline, a prolonged blood elimination half-life (t1/2()), an increase in blood drug concentration, and the appearance of symptoms of theophylline poisoning, such as nausea, vomiting, tremor, restlessness, excitement, convulsions, palpitations, etc. Therefore, the blood drug concentration of theophylline should be measured and the dose adjusted when used in combination. 3. Cyclosporine and this product can increase the blood drug concentration of the former. The blood concentration of cyclosporine must be monitored and the dose adjusted. 4. When this product is used in combination with the anticoagulant warfarin, it can enhance the anticoagulant effect of the latter. When used in combination, the patient's prothrombin time should be closely monitored. 5. Probenecid can reduce the secretion of this product from the renal tubules by about 50%. When used in combination, it may produce toxicity due to the increased blood concentration of this product. 6. This product interferes with the metabolism of caffeine, resulting in a decrease in caffeine clearance, a prolonged blood elimination half-life (t1/2()), and possible central nervous system toxicity.
Specifications	0.4g (calculated as C17H18FN3O3)
Manufacturer	Shandong Beida Gaoke Huatai Pharmaceutical Co., Ltd.

Ciprofloxacin Lactate for Injection
Ingredients	The content of ciprofloxacin lactate should be calculated as ciprofloxacin (C17H18FN3O3), which should be 90.0% to 110.0% of the labeled amount
Indication	1. Urine alkalinizers can reduce the solubility of this product in urine, leading to crystalluria and nephrotoxicity. 2. When this product is used in combination with theophylline, competitive inhibition of the cytochrome P450 binding site may lead to a significant reduction in the hepatic clearance of theophylline, a prolonged blood elimination half-life (t1/2()), an increase in blood drug concentration, and the appearance of symptoms of theophylline poisoning, such as nausea, vomiting, tremor, restlessness, excitement, convulsions, palpitations, etc. Therefore, the blood drug concentration of theophylline should be measured and the dose adjusted when used in combination. 3. Cyclosporine and this product can increase the blood drug concentration of the former. The blood concentration of cyclosporine must be monitored and the dose adjusted. 4. When this product is used in combination with the anticoagulant warfarin, it can enhance the anticoagulant effect of the latter. When used in combination, the patient's prothrombin time should be closely monitored. 5. Probenecid can reduce the secretion of this product from the renal tubules by about 50%. When used in combination, it may produce toxicity due to the increased blood concentration of this product. 6. This product interferes with the metabolism of caffeine, resulting in a decrease in caffeine clearance, a prolonged blood elimination half-life (t1/2()), and possible central nervous system toxicity.
Specifications	0.2g (as ciprofloxacin)
Manufacturer	Hunan Kelun Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

Neuland Laboratories Limited.

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Uquifa Mexico, S.A. de C.V.

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Finland
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