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Difloxacin

Difloxacin structure

CAS No:
98106-17-3
Formula:
C21H19F2N3O3
Chemical Name:
Difloxacin
Synonyms:
3-Quinolinecarboxylic acid,6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-;6-Fluoro-1-(4-fluorophenyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid;A 56619;Difloxacin;Dicural;Difluoxacin;Pulsaflox;99331-53-0
Categories:
Active Pharmaceutical Ingredients > Synthetic Anti-infective Drugs

Description

Whtie-Cream to Yellowish Crystalline Powder

Difloxacin is a quinolone that is pefloxacin in which the ethyl group at position 1 of the quinolone has been replaced by a p-fluorophenyl group. A broad-spectrum antibiotic effective against both Gram-positive and Gram-negative bacteria, it is used (usually as the monohydrochloride salt) for the treatment of bacterial infections in dogs. It has a role as an antibacterial drug and a Mycoplasma genitalium metabolite. It is a quinolone, a N-alkylpiperazine, a N-arylpiperazine, a quinolone antibiotic, a fluoroquinolone antibiotic, a member of monofluorobenzenes and a monocarboxylic acid.|Difloxacin is a synthetic fluoroquinolone used in veterinary. As an antibacterial, it presents a broad bactericidal spectrum and its effects are dependent on its concentration. However, it presents a reduced efficacy when compared to other fluoroquinolone antibacterials.

Difloxacin Basic Attributes

Molecular Weight：

399.39

Exact Mass：

399.39

UNII：

5Z7OO9FNFD

DSSTox ID：

DTXSID5048348

ATC Code：

QJ01MA94|QJ01MA

HScode：

2933990090

Characteristics

PSA：

64.1

XLogP3：

2.72180

Density：

1.409 g/cm3

Melting Point：

279-282 °C @ Solvent: Chloroform, Ethanol

Boiling Point：

595.5ºC at 760 mmHg

Flash Point：

313.9ºC

Collision Cross Section：

192.3 Å² [M+H]+ [CCS Type: TW]|205.3 Å² [M+H]+ [CCS Type: TW, Method: calibrated with Waters Major Mix]|210.4 Å² [M+Na]+ [CCS Type: TW, Method: calibrated with Waters Major Mix]

Drug Information

Drug Indication：

Chickens:for the treatment of chronic respiratory infections caused by sensitive strains of Escherichia coli and Mycoplasma gallisepticum.Turkeys:For the treatment of chronic respiratory infections caused by sensitive strains of Escherichia coli and Mycoplasma gallisepticum.Also for the treatment of infections caused by Pasteurella multocida.Dogs:For the treatment of acute uncomplicated urinary-tract infections caused by Escherichia coli or Staphylococcus spp. and superficial pyoderma caused by Staphylococcus intermedius.Cattle:For the treatment of bovine respiratory disease (shipping fever, calf pneumonia) caused by single or mixed infections with Pasteurella haemolytica, Pasteurella multocida and / or Mycoplasma spp.|In chickens and turkeys Pulsaflox oral solution is indicated for treatment of chronic respiratory infections caused by sensitive strains of Escherichia coli and Mycoplasma gallisepticum.In turkeys Pulsaflox oral solution is also indicated for the treatment of infections caused by Pasteurella multocida.Pulsaflox oral solution should only be used based on susceptibility testing.

MeSH Entry Terms：

1-(4-fluorophenyl)-6-fluoro-7-(4-methyl-1-piperazinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

Difloxacin Use and Manufacturing

Uses

A fluoroquinolone antibacterial structurally related to norfloxacin

Use Classification：

Veterinary drugs -> Dicural -> EMA Drug Category|Antibacterials for systemic use, Antiinfectives for systemic use -> Veterinary pharmacotherapeutic group|Veterinary drugs -> Pulsaflox -> EMA Drug Category|Antibacterials for systemic use -> Veterinary pharmacotherapeutic group|Pharmaceuticals

Computed Properties

Molecular Weight:399.4
XLogP3:1.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:3
Exact Mass:399.13944780
Monoisotopic Mass:399.13944780
Topological Polar Surface Area:64.1
Heavy Atom Count:29
Complexity:672
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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