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NAPHTHOQUINE PHOSPHATE

NAPHTHOQUINE PHOSPHATE structure

CAS No:
173531-58-3
Formula:
C24H28ClN3O.2(H3O4P)
Chemical Name:
NAPHTHOQUINE PHOSPHATE
Synonyms:
NAPHTHOQUINE PHOSPHATE;4-[(7-Chloro-4-quinolinyl)amino]-2-[[(tert-butyl)amino]methyl]-5,6,7,8-tetrahydro-1-naphthalenol phosphate;Naphthalene phosphoric acid phenol quinoline;Naphathoquine Phosphate
Categories:
Active Pharmaceutical Ingredients > Antiparasitic Drugs

Description

Naphthoquine phosphate is antimalarial drug.IC50 Value: N/ATarget: AntiparasiticNaphthoquine phosphate and artemisinine are two antimalarials developed in China. Both drugs have proven to be efficacious and well tolerated as monotherapy as well as in combination in patients suffering from malaria. The Co-naphthoquine, a novel antimalarial combination, is an oral fixed combination tablet of the naphthoquine phosphate and artemisinine. Artemisinin is characterised by a rapid onset of schiz

NAPHTHOQUINE PHOSPHATE Basic Attributes

Molecular Weight：

605.946

Exact Mass：

605.145874

UNII：

M6M6AP4KAH

DSSTox ID：

DTXSID70431766

Characteristics

PSA：

213

XLogP3：

4.71100

Drug Information

MeSH Entry Terms：

naphthoquine

Computed Properties

Molecular Weight:605.9
Hydrogen Bond Donor Count:9
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:5
Exact Mass:605.1458814
Monoisotopic Mass:605.1458814
Topological Polar Surface Area:213
Heavy Atom Count:39
Complexity:589
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes

Drug Function and Efficacy

It has a killing effect on various malarial parasite schizonts and certain species and strains of malarial parasite gametocytes and tissue stage protozoa, and has a good curative effect on drug-resistant malarial parasites; it has a long-term preventive effect on malarial parasites.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Compound naphtholquine phosphate tablets
Ingredients	This product is a compound preparation, and its components are: each tablet contains 50 mg of naphtholquine and 125 mg of artemisinin.
Indication	This product is a compound preparation containing fast-acting artemisinin and long-acting naphthoquine phosphate. The two drugs have a synergistic effect when used together. In animal models, the synergistic index for resistant insect strains is 8.2, while the toxicity is only additive. In clinical trials, this product was used in combination with sedatives or antibiotics, and no adverse effects were observed.
Specifications	Each tablet contains 0.125g artemisinin and 50mg naphtholquine
Manufacturer	KPC Pharmaceuticals, Inc.

Naphthoquine phosphate

Compound naphtholquine phosphate tablets
Ingredients	Naphthoquine phosphate, artemisinin. Chemical name: decahydro-10-methoxy-3,6,9-trimethyl-3,12-oxo-12H-pyrano[4,3-j]-1,2-benzodiphenylamine Molecular weight: C16H26O5
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	Naphthoquine 100 mg + Artemisinin 250 mg
Manufacturer	KPC Pharmaceuticals, Inc.

See More Related Drugs

Registered Holders

KPC Pharmaceuticals, Inc.

China
Active
Shanghai New Hualian Pharmaceutical Co., Ltd.

China
Active