 Home > Encyclopedia > Ceftezole

Ceftezole

Ceftezole structure

CAS No:
26973-24-0
Formula:
C13H12N8O4S3
Chemical Name:
Ceftezole
Synonyms:
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,8-oxo-7-[[2-(1H-tetrazol-1-yl)acetyl]amino]-3-[(1,3,4-thiadiazol-2-ylthio)methyl]-,(6R,7R)-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,8-oxo-7-[2-(1H-tetrazol-1-yl)acetamido]-3-[(1,3,4-thiadiazol-2-ylthio)methyl]-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-3-[(1,3,4-thiadiazol-2-ylthio)methyl]-,(6R-trans)-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-3-[(1,3,4-thiadiazol-2-ylthio)methyl]-,(6R,7R)-;(6R,7R)-8-Oxo-7-[[2-(1H-tetrazol-1-yl)acetyl]amino]-3-[(1,3,4-thiadiazol-2-ylthio)methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;FR 10123;Ceftezole;Ceftezol;CG-B 3Q;CTZ
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Ceftezole (CTZ) is a broad-spectrum cephem antibiotic against many species of gram-positive and gram-negative bacteria. Ceftezole (CTZ) is an alpha-glucosidase inhibitor with in vivo anti-diabetic activity[1][2].

Ceftezole is a first-generation cephalosporin antibiotic having (1,3,4-thiadiazol-2-ylsulfanyl)methyl and [2-(1H-tetrazol-1-yl)acetamido side groups located at positions 3 and 7 respectively. It is a cephalosporin and a member of thiadiazoles.|Ceftezole is a semisynthetic first-generation cephalosporin with antibacterial activity. Ceftezole binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.

Ceftezole Basic Attributes

Molecular Weight：

440.48

Exact Mass：

440.48

UNII：

2Z86SYP11W

DSSTox ID：

DTXSID0022771

NCI Thesaurus Code：

C76038

ATC Code：

J - Antiinfectives for systemic use

HScode：

3003201400

Characteristics

PSA：

235

XLogP3：

0.87

Density：

2.1±0.1 g/cm3

Melting Point：

155 °C (decomp)

Refractive Index：

2.003

Safety Information

hazard class code：

21/22-26-50/53

safety instructions：

28-36/37-45-61

Marks：

T+,N

Precautionary statement(s)：

P261, P272, P280, P285, P302+P352, P304+P341, P321, P333+P313, P342+P311, P363, P501

Hazard Statements：

H317

GHS Classification：

|Danger|H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]|P261, P272, P280, P285, P302+P352, P304+P341, P321, P333+P313, P342+P311, P363, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

MeSH：

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

MeSH Entry Terms：

ceftezol

Computed Properties

Molecular Weight:440.5
XLogP3:-0.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:7
Exact Mass:440.01436441
Monoisotopic Mass:440.01436441
Topological Polar Surface Area:235
Heavy Atom Count:28
Complexity:709
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Ceftezole

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

Ceftezole

CAS No.: 26973-24-0

Content: 99.00%

Inquiry
Shanghai Kangxin Chemical Co., Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of food additives,health ingredients,pharm intermediates

Ceftzole high purity best price pharm ingredients hot sale

CAS No.: 26973-24-0

Grade: medical grade

Content: 99%

Inquiry
Shandong Airuike Chemical Co., Ltd. Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of api,Intermediates,Organic Chemistry,Inorganic Chemistry,Daily Chemicals,Cosmetic Raw Materals,CATALYST AND AUXILIARY,FLAVORS AND FRAGRANCES,Chemical Pesticides,ADDITIVE

CTZ

CAS No.: 26973-24-0

Grade: Pharmaceutical grade

Content: 99%

Inquiry