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Nystatin A1

Nystatin A1 structure

CAS No:
34786-70-4
Formula:
C47H75NO17
Chemical Name:
Nystatin A1
Synonyms:
Amphotericin B,8,9-dideoxy-28,29-dihydro-7,10-dihydroxy-,(7R,10R)-;Nystatin A1;14,39-Dioxabicyclo[33.3.1]nonatriacontane,nystatin A1 deriv.;(7R,10R)-8,9-Dideoxy-28,29-dihydro-7,10-dihydroxyamphotericin B;Stereoisomer of 33-[(3-amino-3,6-dideoxy-β-D-mannopyranosyl)oxy]-1,3,4,7,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,25,27,29,31-hexaene-36-carboxylic acid;(1S,3R,4R,7R,9R,11R,15S,16R,17R,18S,19E,21E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-Amino-3,6-dideoxy-β-D-mannopyranosyl)oxy]-1,3,4,7,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,25,27,29,31-hexaene-36-carboxylic acid;31967-86-9
Categories:
Active Pharmaceutical Ingredients > Antibiotics

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Nystatin A1 Basic Attributes

Molecular Weight：

980.144

Exact Mass：

926.09

HScode：

2942000000

Characteristics

PSA：

347.30000

XLogP3：

1.44310

Density：

1.33g/cm3

Boiling Point：

1132.2ºC at 760mmHg

Flash Point：

638.5ºC

Refractive Index：

1.606

Storage Conditions：

2-8°C

Nystatin A1 Use and Manufacturing

Methods of Manufacturing

The culture solution of the Streptomyces noursei strain is filtered to obtain the hyphae, dried in vacuum at 50-60°C, extracted with methanol, and dried after removing the solvent.

Uses

Biochemical research, high-purity cell culture antiseptic, anti-fungal.

Drug Function and Efficacy

Polyene antifungal drugs have a broad-spectrum antifungal effect and high antibacterial activity against Candida species. Cryptococcus neoformans, Aspergillus, Mucor, Microsporum, Histoplasma capsulatum, Blastomyces dermatitidis and dermatophytes are also usually sensitive to this product. This product can combine with sterols on the fungal cell membrane, causing changes in cell membrane permeability, resulting in the leakage of important cell contents and exerting antifungal effects.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Nystatin Tablets
Ingredients	The main ingredient of this product is nystatin, which is a polyene antifungal antibiotic containing nystatin A1, A3 and polymycin B.
Indication	This experiment has not been conducted and there are no reliable references.
Specifications	500,000 units
Manufacturer	GRAND PHARMACEUTICAL(China) Co., Ltd.