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Isoconazole nitrate

pharmaceutical raw materials
Isoconazole nitrate structure

Isoconazole nitrate 

structure
  • CAS No:

    24168-96-5

  • Formula:

    C18H14Cl4N2O.HNO3

  • Chemical Name:

    Isoconazole nitrate

  • Synonyms:

    1H-Imidazole,1-[2-(2,4-dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]-,nitrate (1:1);Imidazole,1-[2,4-dichloro-β-[(2,6-dichlorobenzyl)oxy]phenethyl]-,mononitrate;1H-Imidazole,1-[2-(2,4-dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]-,mononitrate;Isoconazole nitrate;Adestan G 100;Gyno-Travogen;Fazol;Travogen;R 15454;Travogyn

  • Categories:

    Active Pharmaceutical Ingredients  >  Antibiotics

Description

Isoconazole nitrate is a broad-spectrum antimicrobial agent with a highly effective antimycotic and gram-positive antibacterial activity, a rapid rate of absorption and low systemic exposure potential. Isoconazole nitrate is effective against pathogens involved in dermatomycoses, with minimum inhibitory concentrations well below the concentration of ISN in skin and hair follicles.

Isoconazole nitrate Basic Attributes

479.14

476.981659

246-051-4

2933290090

Characteristics

93.1

6.63030

White crystals or crystalline powder

1.4 g/cm3

182-183 °C

555.1ºC at 760 mmHg

289.5ºC

Refrigerator

Safety Information

NI4772000

P273, P391, P501

H400

|Warning|H400 (94.44%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]|P273, P391, and P501|Aggregated GHS information provided by 37 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. (See all compounds classified as Antifungal Agents.)

1-(2,4-dichloro beta-(2,6-dichlorobenzyloxy)phenethyl) imidazole

Isoconazole nitrate Use and Manufacturing

Antibacterial; antifungal

Computed Properties

Molecular Weight:479.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:478.978717
Monoisotopic Mass:476.981667
Topological Polar Surface Area:93.1
Heavy Atom Count:29
Complexity:431
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Antifungal effect

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Registered Holders

  • ERREGIERRE SPA

    Italy Italy
    Active
  • Sichuan Baili Pharmaceutical Co., Ltd.

    China China
    Inactive
  • JANSSEN PHARMACEUTICA NV

    European Union European Union
    Inactive

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