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Faropenem sodium

Faropenem sodium structure

CAS No:
122547-49-3
Formula:
C12H15NO5S.Na
Chemical Name:
Faropenem sodium
Synonyms:
4-Thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid,6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(2R)-tetrahydro-2-furanyl]-,sodium salt (1:1),(5R,6S)-;4-Thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid,6-(1-hydroxyethyl)-7-oxo-3-(tetrahydro-2-furanyl)-,monosodium salt,[5R-[3(R*),5α,6α(R*)]]-;4-Thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid,6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(2R)-tetrahydro-2-furanyl]-,monosodium salt,(5R,6S)-;SUN 5555;ALP 201;SY 5555;Wy 49605;Furopenem;Faropenem sodium;(5R,6S)-6-[(1R)-1-Hydroxyethyl]-7-oxo-3-[(2R)-2-tetrahydrofuryl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid sodium salt;Fropenem;Farom
Categories:
Active Pharmaceutical Ingredients > Antibiotics

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Description

Pale Yellow Crystals

Faropenem sodium Basic Attributes

Molecular Weight：

307.3

EC Number：

1592732-453-0

Characteristics

Appearance：

white to light brown

Boiling Point：

570.2°C at 760 mmHg

Flash Point：

298.7ºC

Water Solubility：

H2O: ≥20mg/mL

Storage Conditions：

-20°C

Specific rotation：

D22 +60° (c = 0.10)

Safety Information

wgk germany：

Faropenem sodium Use and Manufacturing

Methods of Manufacturing

At room temperature, the intermediate II150g with 1110mL methylene chloride was stirred and dissolved, followed by the addition of triphenylphosphine 18g andSodium caprylate in ethyl acetate (92 g sodium isooctanoate + 1110 mL ethyl acetate) gave a light yellow clear liquid. Replace with N2 for 5 min, add 2.664 g of tetrakis (triphenylphosphine) palladium under N2 protection, After the addition, N2 protection under 25 ~ 30 ° C for 40min; At room temperature, 40 g of purified water was added to the reaction liquid, 20 ~ 30 ° C crystallization 2h, cooled to -5 ~ 0 ° C , Stirring 2h, suction filtration, The filter cake was rinsed with 200 mL × 3 ethyl acetate, Filter cake 35 ~ 40 ° C vacuum drying, Have white powder 119g, the molar yield of 73.3percentThe concentrated product obtained in the above was dissolved in 600 ml of tetrahydrofuran, and a mixed solution of 100.0 g of sodium 2-ethylhexanoate in tetrahydrofuran (200 ml) and water (200 ml) was added and stirred at room temperature for 2 h. A light yellow solid was formed, filtered, and the crude product of faroconin sodium was 147.0g.;_Example 6;_The solid was dissolved in deionized water (2200 ml) at room temperature and acetone was slowly added with stirring until the solution began to become cloudy. When about 750 ml of acetone was added. The solution began to become turbid, stop adding, continue to stir the crystal overnight, pumping, acetone washing, drying, to be white faropernan sodium boutique 125.0g.

Uses

Fully synthetic penicillin antibiotics

Drug Function and Efficacy

By binding to penicillin binding protein (PBP), it inhibits bacterial cell wall synthesis, causing bacterial cell wall defects, bacterial swelling and lysis; triggering bacterial autolytic enzyme activity, showing drug resistance to mutant strains lacking autolytic enzymes. It has low toxicity to the host and has a selective bactericidal effect.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Faropenem Sodium Capsules
Ingredients	Chemical name: ()-(5R, 6S)-6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(2R)-tetrahydro-2-furyl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid sodium salt Molecular weight: C12H14NNaO5S?H2O
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	0.1g (based on C12H15NO5S)

Faropenem sodium

Faropenem sodium

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Registered Holders

Shaoxing Jingxin Pharmaceutical Co., Ltd.

China
Active
Hunan Warrant Chiral Pharmaceutical Co., Ltd.

China
Active
Shandong Chenlong Pharmaceutical Co., Ltd.

China
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