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Sisomicin

Sisomicin structure

CAS No:
32385-11-8
Formula:
C19H37N5O7
Chemical Name:
Sisomicin
Synonyms:
D-Streptamine,O-3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-D-glycero-hex-4-enopyranosyl-(1→4)]-2-deoxy-;Sisomicin;O-3-Deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-D-glycero-hex-4-enopyranosyl-(1→4)]-2-deoxy-D-streptamine;Antibiotic 66-40;Rickamicin;Sch 13475;Siseptin;Antibiotic 6640;BactoCeaze;Ensamycin;34406-63-8;37332-59-5;53179-08-1
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Off-White Solid

Sisomycin is an amino cyclitol glycoside, an aminoglycoside antibiotic, a beta-L-arabinoside and a monosaccharide derivative.|Sisomicin has been used in trials studying the treatment of Pyoderma.|Sisomicin is a broad-spectrum aminoglycoside antibiotic isolated from Micromonospora inyoensis. Sisomicin is strucurally similar to gentamicin but has a unique unsaturated diamino sugar. Of the aminoglycoside antibiotics, sisomicin has the greatest activity against gram-positive bacteria.|Antibiotic produced by Micromonospora inyoensis. It is closely related to gentamicin C1A, one of the components of the gentamicin complex (GENTAMICINS).

Sisomicin Basic Attributes

Molecular Weight：

545.607

Exact Mass：

447.53

EC Number：

251-018-2

UNII：

X55XSL74YQ

DSSTox ID：

DTXSID0023583

NCI Thesaurus Code：

C72569

ATC Code：

J - Antiinfectives for systemic use

Characteristics

PSA：

296.70000

Density：

1.38g/cm3

Melting Point：

80-93°C

Boiling Point：

676.6ºC at 760mmHg

Flash Point：

363ºC

Refractive Index：

1.7600 (estimate)

Storage Conditions：

Hygroscopic, -20°C Freezer, Under Inert Atmosphere

Safety Information

GHS Classification：

|Danger|H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]|P201, P202, P261, P271, P280, P281, P302+P352, P304+P312, P304+P340, P308+P313, P312, P322, P363, P405, and P501|Aggregated GHS information provided by 2 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins. (See all compounds classified as Protein Synthesis Inhibitors.)|Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

MeSH Entry Terms：

4,5 Dehydrogentamicin

Sisomicin Use and Manufacturing

antibacterial, binds to ribosomes

Computed Properties

Molecular Weight:447.5
XLogP3:-5.1
Hydrogen Bond Donor Count:8
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:6
Exact Mass:447.26929854
Monoisotopic Mass:447.26929854
Topological Polar Surface Area:214
Heavy Atom Count:31
Complexity:643
Defined Atom Stereocenter Count:11
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Sisomicin

Hangzhou Dawn Ray Pharmaceutical Co.,Ltd Contact Supplier

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5 YRS

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Sisomicin >=98.0% the intermediate of sisomicin sulfate made in china

CAS No.: 32385-11-8

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Shandong Airuike Chemical Co., Ltd. Contact Supplier

CN
3 YRS

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Trader Supplier of api,Intermediates,Organic Chemistry,Inorganic Chemistry,Daily Chemicals,Cosmetic Raw Materals,CATALYST AND AUXILIARY,FLAVORS AND FRAGRANCES,Chemical Pesticides,ADDITIVE

Sisomicin

CAS No.: 32385-11-8

Grade: Analytical Reagent

Content: 99%

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