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Liranaftate

Liranaftate structure

CAS No:
88678-31-3
Formula:
C18H20N2O2S
Chemical Name:
Liranaftate
Synonyms:
Carbamothioic acid,N-(6-methoxy-2-pyridinyl)-N-methyl-,O-(5,6,7,8-tetrahydro-2-naphthalenyl) ester;Carbamothioic acid,(6-methoxy-2-pyridinyl)methyl-,O-(5,6,7,8-tetrahydro-2-naphthalenyl) ester;Piritetrate;Liranaftate;M 732;O-5,6,7,8-Tetrahydro-2-naphthyl 6-methoxy-2-pyridyl(methyl)thiocarbamate;O-(5,6,7,8-Tetrahydro-2-naphthyl) N-(6-methoxy-2-pyridyl)-N-methylthiocarbamate;Zefnart
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Liranaftate is a squalene epoxidase inhibitor with anti-fungicidal activities. Target: AntifungalLiranaftate showed excellent fungistatic activity against the conidia of T. rubrum. For each of these agents, the MIC after 14 days of contact was 0.009 g/ml. The liranaftate-induced decrease in the MCC occurred from 9 days onwards; MCC at 14 days was 0.039 g/ml [1]. In time-kill studies, liranaftate showed the greatest decrease to a below detection limit in viable counts of T rubrum. The deg

Liranaftate is a member of tetralins.|Liranaftate is a thiocarbamate and squalene epoxidase inhibitor with antifungal activity. Liranaftate inhibits fungal squalene epoxidase, an enzyme that plays a key role in the synthesis of sterol which is essential for cell membrane integrity. By preventing ergosterol synthesis and causing accumulation of squalene, this agent increases cell membrane permeability, cell leakage and eventually cell lysis.

Liranaftate Basic Attributes

Molecular Weight：

328.43

Exact Mass：

328.43

EC Number：

-0

UNII：

5253IGO5X3

DSSTox ID：

DTXSID6046470

NCI Thesaurus Code：

C66019

Characteristics

PSA：

66.7

XLogP3：

4.9

Appearance：

white crystalline solid

Density：

1.2±0.1 g/cm3

Melting Point：

98.5-99.5°C

Boiling Point：

462.5°C at 760 mmHg

Flash Point：

233.5±31.5 °C

Refractive Index：

1.642

Storage Conditions：

-20°C Freezer

Safety Information

RTECS Number：

FD3890000

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P272, P280, P302+P352, P305+P351+P338, P321, P332+P313, P333+P313, P337+P313, P362, P363, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

MeSH Entry Terms：

liranaftate

Liranaftate Use and Manufacturing

A squalene epoxidase inhibitor.Used as an antifungal

Computed Properties

Molecular Weight:328.4
XLogP3:4.9
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:328.12454906
Monoisotopic Mass:328.12454906
Topological Polar Surface Area:66.7
Heavy Atom Count:23
Complexity:407
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Extract from the above information

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

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Registered Holders

Jiangsu Hengfeng Pharmaceutical Co., Ltd.

China
Active
Hunan Jiudian HONGYANG Pharmaceutical Co., Ltd.

China
Active
Shandong Chenlong Pharmaceutical Co., Ltd.

China
Active

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