Halofuginone hydrobromide
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Halofuginone hydrobromide
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CAS No:
64924-67-0
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Formula:
C16H17BrClN3O3.BrH
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Chemical Name:
Halofuginone hydrobromide
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Synonyms:
4(3H)-Quinazolinone,7-bromo-6-chloro-3-[3-[(2R,3S)-3-hydroxy-2-piperidinyl]-2-oxopropyl]-,hydrobromide (1:1),rel-;4(3H)-Quinazolinone,7-bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-,monohydrobromide,trans-(±)-;4(3H)-Quinazolinone,7-bromo-6-chloro-3-[3-[(2R,3S)-3-hydroxy-2-piperidinyl]-2-oxopropyl]-,monohydrobromide,rel-;RU 19110;Stenorol;Halofuginone hydrobromide;4(3H)-Quinazolinone,7-bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-,monohydrobromide,trans-
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CAS No:
Description
Halofuginone hydrobromide (RU-19110 hydrobromide) is a less-toxic form of Febrifugine, which is isolated from the plant Dichroa febrifuga[1]. Halofuginone inhibits prolyl-tRNA synthetase in an ATP-dependent manner with a Ki of 18.3 nM[2]. Halofuginone attenuates osteoarthritis (OA) by inhibition of TGF-β activity[3].
Safety Information
UN2811 - class 6.1 - PG 1 - EHS - Toxic solids, organic, n.o.s., HI: all
3
22
VA2397066
Xn
P264, P270, P301+P312, P330, P501
H302
Halofuginone hydrobromide Use and Manufacturing
Halogenated derivative of Febrifugine. Used as an antiprotozoal (coccidiostat).
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