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Home > Encyclopedia > tert-Butyl N-(4-aminobutyl)carbamate

tert-Butyl N-(4-aminobutyl)carbamate

tert-Butyl N-(4-aminobutyl)carbamate structure

tert-Butyl N-(4-aminobutyl)carbamate 

structure
  • CAS No:

    68076-36-8

  • Formula:

    C9H20N2O2

  • Chemical Name:

    tert-Butyl N-(4-aminobutyl)carbamate

  • Synonyms:

    RARECHEM AR PA 0023;TERT-BUTYL N-(4-AMINOBUTYL)CARBAMATE;N-TERT-BUTYLOXYCARBONYL-1,4-DIAMINOBUTANE HYDROCHLORIDE;N-T-BUTYLOXYCARBONYL-1,4-DIAMINOBUTANE HYDROCHLORIDE;N-(TERT-BUTOXYCARBONYL)-1,4-BUTANEDIAMINE;N-(TERT-BUTOXYCARBONYL)-1,4-DIAMINOBUTANE;N-T-BOC-BUTANDIAMINE HCL;N-BOC-1,4-BUTANEDIAMINE

  • Categories:

    Organic Chemistry  >  Amides

Description

NH2-C4-NH-Boc (compound 15) is a PROTAC linker, which refers to the Alkyl/ether composition. NH2-C4-NH-Boc can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

tert-Butyl N-(4-aminobutyl)carbamate Basic Attributes

188.27

188.152481

2924199090

Characteristics

64.4

0.7

Clear colorless to light yellow Liquid

1.0±0.1 g/cm3

292.8°C at 760 mmHg

109 °C

1.457

Safety Information

8

UN 2735 8/PG 3

3

34-24

26-36/37/39-45

C

P280-P305 + P351 + P338-P310

H314

|Danger|H314 (85.71%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]|P260, P264, P280, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P332+P313, P337+P313, P362, P363, P405, and P501|Aggregated GHS information provided by 7 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

tert-Butyl N-(4-aminobutyl)carbamate Use and Manufacturing

suzuki reaction

Computed Properties

Molecular Weight:188.27
XLogP3:0.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:188.152477885
Monoisotopic Mass:188.152477885
Topological Polar Surface Area:64.4
Heavy Atom Count:13
Complexity:152
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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