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Carfilzomib

Carfilzomib structure

CAS No:
868540-17-4
Formula:
C40H57N5O7
Chemical Name:
Carfilzomib
Synonyms:
Carfilzomib;N-{(2S)-2-[(Morpholin-4-ylacetyl)aMino]-4-phenylbutanoyl}-L-leucyl-N-{(2S)-4-Methyl-1-[(2R)-2-Methyloxiran-2-yl]-1-oxopentan-2-yl}-L-phenylalaninaMide;CarfilzoMib salt;CarfilzoMib/PR 171;PR-171 (CarfilzoMib);(alphaS)-alpha-[(4-Morpholinylacetyl)amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyloxiranyl]carbonyl]butyl]-L-phenylalaninamide;CarfilzoMib, Free Base, >99%;(S)-4-Methyl-N-((S)-1-((S)-4-Methyl-1-((R)-2- Methyloxiran-2-yl)-1 -oxopentan-2-ylaMino)-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-(2-MorpholinoacetaMido)-4-phenylbutanaMido)pentanaMide
Categories:
Biochemical Engineering > Inhibitors

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Description

Carfilzomib is an irreversible proteasome inhibitor with an IC50 of 5 nM in ANBL-6 and RPMI 8226 cells.

Carfilzomib Basic Attributes

Molecular Weight：

719.90988

Exact Mass：

719.425781

EC Number：

1592732-453-0

HScode：

29337900

Characteristics

PSA：

159

XLogP3：

6.71

Density：

1.2±0.1 g/cm3

Boiling Point：

975.6±65.0 °C at 760 mmHg

Flash Point：

543.8℃

Refractive Index：

1.551

Water Solubility：

H2O: Insoluble

Safety Information

Precautionary statement(s)：

P201, P202, P260, P264, P270, P280, P281, P302+P352, P305+P351+P338, P308+P313, P314, P321, P332+P313, P337+P313, P362, P405, P501

Hazard Statements：

H315

Carfilzomib Use and Manufacturing

Carfilzomib is a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.

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