Ponatinib
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Ponatinib
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CAS No:
943319-70-8
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Formula:
C29H27F3N6O
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Chemical Name:
Ponatinib
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Synonyms:
Benzamide,3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-;3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]benzamide;Ponatinib;AP 24534;Iclusig;952306-26-2
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CAS No:
Description
Ponatinib is a potent, orally available multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively.
Characteristics
65.8
4.1
1.3±0.1 g/cm3
1.622
In water, 9.0X10-2 mg/L at 25 deg C (est)
2.5X10-17 mm Hg at 25 deg C (est)
Ponatinib Use and Manufacturing
Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM, respectively
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