1,2-Dibromo-4,5-difluorobenzene
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1,2-Dibromo-4,5-difluorobenzene
structure -
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CAS No:
64695-78-9
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Formula:
C6H2Br2F2
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Chemical Name:
1,2-Dibromo-4,5-difluorobenzene
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Synonyms:
Benzene,1,2-dibromo-4,5-difluoro-;1,2-Dibromo-4,5-difluorobenzene;1,2-Difluoro-4,5-dibromobenzene;NSC 10239
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CAS No:
1,2-Dibromo-4,5-difluorobenzene Basic Attributes
271.88
271.88
1941132
265-021-1
56N35RZH2F
10239
DTXSID50215026
2903999090
Characteristics
0
3.5
white to yellow, low melting solid
2.1±0.1 g/cm3
33-35 °C(lit.)
216.2ºC at 760 mmHg
112 °F
1.552
H2O: insoluble
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Safety Information
Ⅱ
4.1
UN 1325 4.1/PG 2
3
10-36/37/38
16-26-36/37/39-24/25
Xi
Irritant
Stable at room temperature in closed containers under normal storage and handling conditions.
P261-P305 + P351 + P338
H226-H315-H319-H335
|Warning|H226 (82.61%): Flammable liquid and vapor [Warning Flammable liquids]|P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P370+P378, P403+P233, P403+P235, P405, and P501|Aggregated GHS information provided by 46 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
1,2-Dibromo-4,5-difluorobenzene Use and Manufacturing
First, 84 mg (1.5 mmol) of iron powder was dispersed in 7.53 g (50 mmol) of 1, 2-difluorobenzene, and the internal temperature was adjusted to 20°C. Subsequently, 18.4 g (115 mmol) of bromine was added dropwise over a period of 50 minutes. During this period, the internal temperature was maintained at about 20°C. Following the completion of the dropwise addition of bromine, the internal temperature was raised to 40°C, the mixture was reacted for 2 hours, and the internal temperature was then further raised to 50°C and the reaction was continued for a further 2 hours. Following completion of the reaction, the reaction mixture was cooled to room temperature and poured into an aqueous solution prepared by dissolving 25.2 g of sodium bicarbonate and 12.6 g of sodium sulfite in 100 ml of water. The product was then extracted with ethyl acetate. The extracted solution was washed once with each of water and a saturated saline solution, and was then dried over magnesium sulfate. Following removal of the magnesium sulfate by filtration, quantitative analysis of the solution by HPLC revealed a reaction yield of 94percent of the target product 1, 2-dibromo-4, 5-difluorobenzene.
Intermediate for medicine, pesticide, liquid crystal material.
Computed Properties
Molecular Weight:271.88
XLogP3:3.5
Hydrogen Bond Acceptor Count:2
Exact Mass:271.84708
Monoisotopic Mass:269.84913
Heavy Atom Count:10
Complexity:106
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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