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(2E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide

(2E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide structure

CAS No:
133550-30-8
Formula:
C17H14N2O3
Chemical Name:
(2E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide
Synonyms:
2-Propenamide,2-cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-,(2E)-;2-Propenamide,2-cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-,(E)-;(2E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide;AG 490;Tyrphostin AG 490
Categories:
Biochemical Engineering > Amino Acids and Derivatives

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Description

AG-490 is a tyrosine kinase inhibitor that inhibits EGFR, Stat-3 and JAK2/3.

(2E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide Basic Attributes

Molecular Weight：

294.3

Exact Mass：

294.30

HScode：

29269090

Characteristics

PSA：

93.4

XLogP3：

2.4

Appearance：

yellow solid

Density：

1.337

Melting Point：

215°C(lit.)

Boiling Point：

615.2±55.0 °C(Predicted)

Flash Point：

325.9±31.5 °C

Refractive Index：

1.679

Water Solubility：

ethanol: 5 mg/mL

Storage Conditions：

−20°C

Safety Information

Packing level：

III

Hazard category：

6.1

Transport codes：

UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all

wgk germany：

hazard class code：

36/37/38-50-25

safety instructions：

26-36-61-45

RTECS Number：

UC6316197

Marks：

Xi,N,T

Precautionary statement(s)：

P273-P301 + P310

Hazard Statements：

H301-H400

(2E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide Use and Manufacturing

AG 490 is a potent epidermal growth factor receptor kinase autophosphorylation inhibitor with an IC50 of 100 nM and 56.8 μM for EGFR and JAK, respectively.

Recommended Suppliers of (2E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

Tyrphostin AG 490

CAS No.: 133550-30-8

Content: 99.00%

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Henan Lihao Chem Plant Limited Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of PVC resin,pvc paste resin,melamine

Tyrphostin AG 490 99% see COA Kanbei kanbei

CAS No.: 133550-30-8

Grade: Industrial Grade

Content: 99%

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Guide of (2E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Recommended Suppliers
Learn More Other Chemicals

(2E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide

SDS

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