α-Tosyl-L-arginine methyl ester
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α-Tosyl-L-arginine methyl ester
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CAS No:
901-47-3
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Formula:
C14H22N4O4S
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Chemical Name:
α-Tosyl-L-arginine methyl ester
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Synonyms:
L-Arginine,N2-[(4-methylphenyl)sulfonyl]-,methyl ester;Arginine,N2-(p-tolylsulfonyl)-,methyl ester,L-;Arginine,(p-tolylsulfonyl)-,methyl ester;TAME (pharmaceutical);α-N-p-Toluenesulfonyl-L-arginine methyl ester;Methyl p-toluenesulfonyl-L-argininate;Methyl Nα-p-toluenesulfonyl-L-argininate;α-Tosyl-L-arginine methyl ester;p-Toluenesulfonyl-L-arginine methyl ester;p-Tolylsulfonyl-L-arginine methyl ester;N1-Tosyl-L-arginine methyl ester;p-Tosyl-L-arginine methyl ester;N-α-Toluenesulfonyl-L-arginine methyl ester;α-N-p-Tosyl-L-arginine methyl ester;TAME;(S)-Methyl 5-guanidino-2-(4-methylphenylsulfonamido)pentanoate;2706-74-3
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CAS No:
Description
TAME is an inhibitor of anaphase-promoting complex (APC), which prevents its activation by Cdc20 and Cdh1; TAME is also an inhibitor of cyclin proteolysis in mitotic Xenopus egg extract, with an IC50 of 12 µM.
TAMe is an L-arginine ester that is methyl L-argininate in which one of the hydrogens attached to the alpha-nitrogen is substituted by a tosyl group. It is a L-arginine ester, a sulfonamide, a methyl ester and a member of guanidines.|Arginine derivative which is a substrate for many proteolytic enzymes. As a substrate for the esterase from the first component of complement, it inhibits the action of C(l) on C(4).
Characteristics
142.75000
0.77
1.3±0.1 g/cm3
-80°C
516.5±60.0 °C at 760 mmHg
266.1±32.9 °C
1.591
Relative vapour density (air = 1): 3.6
Explosive limits , vol% in air: 1.1-7.1
α-Tosyl-L-arginine methyl ester Use and Manufacturing
Tosyl-L-Arginine Methyl Ester (TAME) is an APC inhibitor.
Computed Properties
Molecular Weight:342.42
XLogP3:0.4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:9
Exact Mass:342.13617637
Monoisotopic Mass:342.13617637
Topological Polar Surface Area:145
Heavy Atom Count:23
Complexity:503
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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