4-Phosphonophenylglycine
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4-Phosphonophenylglycine
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CAS No:
120667-15-4
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Formula:
C8H10NO5P
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Chemical Name:
4-Phosphonophenylglycine
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Synonyms:
(RS)-PHOSPHONOPHENYLGLYCINE;(RS)-PPG;(RS)-4-PHOSPHONOPHENYLGLYCINE;4-Phosphonophenylglycine
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CAS No:
Description
(RS)-PPG is a potent and selective agonist for group III mGluRs. The EC50s of 5.2 μM, 4.7 μM, 185 μM, and 0.2 μM for hmGluR4a, hmGluR6, hmGluR7b, and hmGluR8a, respectively. Anticonvulsive and neuroprotective activity[1].
Characteristics
130.66000
0.27430
1.61±0.1 g/cm3(Predicted)
515.5±60.0 °C(Predicted)
1.617
DMSO: soluble2mg/mL
Store at RT
4-Phosphonophenylglycine Use and Manufacturing
A potent and selective group III metabotropic glutamate receptor agonist, with approximately 25-fold preference for hmGlu 8 ; anticonvulsant and neuroprotective in vivo . Also available as part of the Group III mGlu Receptor Tocriset™ .
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