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D(+)-Galactosamine hydrochloride

D(+)-Galactosamine hydrochloride structure

CAS No:
1772-03-8
Formula:
C6H14ClNO5
Chemical Name:
D(+)-Galactosamine hydrochloride
Synonyms:
D-GALACTOSAMINE HYDROCHLORIDE extrapure;2-Amino-2-deoxy-D-galactopyranose hydrochloride, D-Chondrosamine hydrochloride, Chondrosamine;(2R,3R,4R,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride;D(+)-Galactosamine hydrochloride,99%;D-Glactosamine Hydrochloride;D-Galactosamine hydrochloride ,97%;D(+)-Galactosamine h;D-Galactosamine hydrochloride ,98.5%
Categories:
Biochemical Engineering > Saccharides

Description

White Crystalline Solid

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Dissolve the hydrochloride in a small volume of H2O. Then add three volumes of EtOH, followed by acetone until faintly turbid and keep overnight in a refrigerator. [Roseman & Ludoweig J Am Chem Soc 76 301 1954, Beilstein 4 IV 2024.]

D(+)-Galactosamine hydrochloride Basic Attributes

Molecular Weight：

215.63

Exact Mass：

215.056046

BRN：

3697825

EC Number：

217-198-1

UNII：

U51H7Z9859

TSCA：

TSCA listed

Color/Form：

White to Off-White

HScode：

29329970

Characteristics

PSA：

116.17000

XLogP3：

-1.75270

Appearance：

White powder

Density：

1.3965 (rough estimate)

Melting Point：

182-185 °C (dec.)(lit.)

Boiling Point：

449°C at 760 mmHg

Flash Point：

275.8ºC

Refractive Index：

96 ° (C=1, H2O)

Water Solubility：

SOLUBLE

Storage Conditions：

Storeat2-8

Vapor Pressure：

5.53E-10mmHg at 25°C

Specific rotation：

96 º (589nm c=1,H2O,24 hrs)

Critical Temperature & Pressure：

room temp

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

safety instructions：

24/25-36/37/39-27-26

RTECS Number：

LW5500000

Marks：

Stability/Shelf Life：

Moisture Sensitive

Hazard Statements：

36/37/38

D(+)-Galactosamine hydrochloride Use and Manufacturing

Uses

Specifically inhibits COX-2 by preventing COX-2 N-glycosylation and by increasing COX-2 protein turnover in a proteasome-dependent manner.

D-(+)-Galactosamine (D-chondrosamine) is used with lipopolysaccharides (LPS) to induce models of acute hepatic failure (LPS/D-GalN-induced liver injury, hepatitis) for therapeutic research to find new drugs.

D-(+)-Galactosamine hydrochloride has been used to:induce livery injuryinflammatory liver injuryacute liver failure (ALF) in mice

Manufacturing Info：

D-Galactose, 2-amino-2-deoxy-, hydrochloride (1:1): ACTIVE

Computed Properties

Molecular Weight:215.63
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:215.0560502
Monoisotopic Mass:215.0560502
Topological Polar Surface Area:124
Heavy Atom Count:13
Complexity:142
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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D(+)-Galactosaminehydrochloride

CAS No.: 1772-03-8

Grade: Analytical Reagent

Content: 99%

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Guide of D(+)-Galactosamine hydrochloride

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
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D(+)-Galactosamine hydrochloride

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