4-Thiouridine
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4-Thiouridine
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CAS No:
13957-31-8
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Formula:
C9H12N2O5S
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Chemical Name:
4-Thiouridine
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Synonyms:
Uridine,4-thio-;4-Thiouridine;Thiouridine;NSC 518132;17676-63-0
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CAS No:
Description
ChEBI: A thiouridine in which the oxygen replaced by sulfur is that at C-4.
4-thiouridine is a thiouridine in which the oxygen replaced by sulfur is that at C-4. It has a role as an affinity label and an antimetabolite. It is a thiouridine and a nucleoside analogue.|A photoactivable URIDINE analog that is used as an affinity label.
Characteristics
134
-1.4
light yellow crystalline
1.72±0.1 g/cm3(Predicted)
139-140 °C @ Solvent: Ethanol
1.733
Soluble in water (20 mg/ml), and methanol (10 mg/ml).
−20°C
Drug Information
Analogs of those substrates or compounds which bind naturally at the active sites of proteins, enzymes, antibodies, steroids, or physiological receptors. These analogs form a stable covalent bond at the binding site, thereby acting as inhibitors of the proteins or steroids. (See all compounds classified as Affinity Labels.)|Drugs that are chemically similar to naturally occurring metabolites, but differ enough to interfere with normal metabolic pathways. (From AMA Drug Evaluations Annual, 1994, p2033) (See all compounds classified as Antimetabolites.)
4 Thiouridine
4-Thiouridine Use and Manufacturing
4-Thiouridine is a photoreactive (crosslinking) uridine analogue that upon phosphorylation to 4-thioUTP may be incorporated into RNA structures. 4-Thiouridine may be used to study the specificity and kinetics of uridine-cytidine kinases.
Computed Properties
Molecular Weight:260.27
XLogP3:-1.4
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:260.04669266
Monoisotopic Mass:260.04669266
Topological Polar Surface Area:134
Heavy Atom Count:17
Complexity:374
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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