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2'-C-Methylcytidine

2'-C-Methylcytidine structure

CAS No:
20724-73-6
Formula:
C10H15N3O5
Chemical Name:
2'-C-Methylcytidine
Synonyms:
2'-C-METHYLCYTIDINE;2'-CMethyl-D-cytidine;2''-METHYLCYTIDINE;1-(2-C-Methyl-β-D-ribofuranosyl)cytosine;NM-107;2'-C-Methyl-1-β-D-ribofuranosylcytosine
Categories:
Biochemical Engineering > Saccharides

Description

NM107 is a inhibitors of HCV RNA replication with IC50 of 7.0 μM in vitro.IC50 value: 7.0 μMTarget:HCV RNA replicationNM107 is a potent and selective inhibitor of flavi- and pesti-virus replication in cell culture, with inhibitory activity and cytotoxicity against HCV 1b replicon cells, IC50 is 1.13 μM. Intracellular HCV RNA in HCV-infected cells treated the HCV polymerase inhibitor NM107 shows a similar pattern of decline. NM107 are currently being investigated as additional therapeutic

A nucleoside analog with anti-hepatitis C virus (HCV) activity. Upon phosphorylation into its 5-triphosphate form, this metabolite inhibits viral RNA chain elongation and viral RNA-dependent RNA polymerase activity. This blocks viral production of HCV RNA and thus viral replication.

2'-C-Methylcytidine Basic Attributes

Molecular Weight：

257.24

Exact Mass：

257.101166

UNII：

27FS20C1D8

DSSTox ID：

DTXSID40174799

HScode：

2934999090

Characteristics

PSA：

129

XLogP3：

-2.4

Appearance：

white to off-white

Density：

1.7±0.1 g/cm3

Melting Point：

243-245°C

Boiling Point：

523.9°C at 760 mmHg

Flash Point：

270.7±32.9 °C

Refractive Index：

1.700

Water Solubility：

H2O: >20mg/mL

Storage Conditions：

Hygroscopic, -20°C Freezer, Under Inert Atmosphere

Vapor Pressure：

3.63E-13mmHg at 25°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38

safety instructions：

Marks：

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H315-H319-H335

Drug Information

MeSH Entry Terms：

2'-C-methyl-cytidine

Computed Properties

Molecular Weight:257.24
XLogP3:-2.4
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:257.10117059
Monoisotopic Mass:257.10117059
Topological Polar Surface Area:129
Heavy Atom Count:18
Complexity:424
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of 2'-C-Methylcytidine

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Computed Properties
Learn More Other Chemicals

2'-C-Methylcytidine

SDS

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