4-Quinazolinamine, N-(3-bromophenyl)-6,7-dimethoxy-, hydrochloride (1:1)
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4-Quinazolinamine, N-(3-bromophenyl)-6,7-dimethoxy-, hydrochloride (1:1)
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CAS No:
183322-45-4
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Formula:
C16H14BrN3O2.ClH
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Chemical Name:
4-Quinazolinamine, N-(3-bromophenyl)-6,7-dimethoxy-, hydrochloride (1:1)
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Synonyms:
4-Quinazolinamine,N-(3-bromophenyl)-6,7-dimethoxy-,hydrochloride (1:1);4-Quinazolinamine,N-(3-bromophenyl)-6,7-dimethoxy-,monohydrochloride;6,7-Dimethoxy-4-[N-(3-bromophenyl)amino]quinazoline hydrochloride
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CAS No:
Description
ChEBI: A hydrochloride obtained by combining PD-153035 with one equivalent of hydrochloric acid.
PD-153035 hydrochloride is a hydrochloride obtained by combining PD-153035 with one equivalent of hydrochloric acid. It has a role as an epidermal growth factor receptor antagonist and an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor. It contains a PD-153035(1+).
4-Quinazolinamine, N-(3-bromophenyl)-6,7-dimethoxy-, hydrochloride (1:1) Basic Attributes
396.669
395.003601
AHJ252P69N
DTXSID30171414
2933990090
Characteristics
56.3
white to beige
256-257.5 °C
472.1°C at 760 mmHg
239.3ºC
DMSO: soluble2mg/mL, clear (warmed)
2-8°C
Safety Information
UN 2811 6.1 / PGIII
3
25-37/38-41
26-39-45
T
P261-P280-P301 + P310-P305 + P351 + P338
H301-H315-H318-H335
4-Quinazolinamine, N-(3-bromophenyl)-6,7-dimethoxy-, hydrochloride (1:1) Use and Manufacturing
PD153035 is an inhibitor of EGFR, competitive with ATP. EGF Receptor: IC50 = 25 pM (Ki = 6 pM).
Computed Properties
Molecular Weight:396.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:395.00362
Monoisotopic Mass:395.00362
Topological Polar Surface Area:56.3
Heavy Atom Count:23
Complexity:360
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
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4-Quinazolinamine, N-(3-bromophenyl)-6,7-dimethoxy-, hydrochloride (1:1)
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