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SB269970 HCl

SB269970 HCl structure

CAS No:
261901-57-9
Formula:
C18H28N2O3SHCl
Chemical Name:
SB269970 HCl
Synonyms:
(r)-3-[2-[2-(4-methylpiperidin-1-yl)ethyl]pyrrolidine-1-sulfonyl]phenol hydrochloride;SB269970A,(R)-3-[2-[2-(4-Methylpiperidin-1-yl)ethyl]pyrrolidine-1-sulfonyl]phenolhydrochloride;SB-269970A;(R)-3-((2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidin-1-yl)sulfonyl)phenol hydrochloride;(2R)-1-[(3-Hydroxyphenyl)sulfonyl]-2-[2-(4-methyl-1-piperidinyl)ethyl]pyrrolidine monohydrochloride;Phenol, 3-[[(2R)-2-[2-(4-methyl-1-piperidinyl)ethyl]-1-pyrrolidinyl]sulfonyl]-, hydrochloride (1:1);SB269970 hydrochloride, >=98%
Categories:
Biochemical Engineering > Inhibitors

Description

SB269970 hydrochloride is a hydrochloride salt form of SB-269970, which is a 5-HT7 receptor antagonist with pKi of 8.3, exhibits >50-fold selectivity against other receptors.IC50 Value: 8.3 (pKi for 5-HT7) [1]Target: 5-HT7 receptorin vitro: 5-CT-stimulated adenylyl cyclase activity in guinea-pig hippocampal membranes (pEC(50) of 8.4+/-0.2) was inhibited by SB-269970-A (0.3 microM) with a pK(B) (8.3+/-0.1) in good agreement with its antagonist potency at the human cloned 5-HT(7(a)) recept

SB269970 HCl Basic Attributes

Molecular Weight：

388.951

Exact Mass：

388.15900

HScode：

2935009090

Characteristics

PSA：

69.2

XLogP3：

4.42590

Water Solubility：

H2O: soluble10mg/mL, clear (warmed to 60 °C)

Storage Conditions：

2-8°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

Computed Properties

Molecular Weight:389.0
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:388.1587417
Monoisotopic Mass:388.1587417
Topological Polar Surface Area:69.2
Heavy Atom Count:25
Complexity:497
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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SB269970 HCl

CAS No.: 261901-57-9

Content: 99.00%

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CAS No.: 261901-57-9

Grade: Industrial Grade

Content: 99%

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